Thomas Seyfried

Insights for Ambitious Fathers: https://dynastyfoundry.com/YTLetters Cancer is killing thousands of people every day, and much of it is from the treatment. Professor Thomas Seyfried explains what we're doing wrong, how to prevent and manage cancer, and reveals the truth about the disease revealed by his over 30 years in the field. Donate to Professor Seyfried's work: https://tomseyfried.com/donate/ Professor Seyfried's research: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html Professor Seyfried on YouTube: https://www.youtube.com/@TalkingCancer-u4k

Thomas N. Seyfried is Professor of Biology at Boston College and received his Ph.D. in Genetics and Biochemistry from the University of Illinois in 1976. He did his undergraduate work at the University of New England where he received a distinguished Alumni Achievement Award. He also holds a master’s degree in Genetics from Illinois State University, Normal, IL. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Professor Seyfried previously served as Chair of the Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association. He has received the Lifetime Achievement Awards from the Academy of Complimentary and Integrative Medicine, the International Dose Response Society, and the Uncompromising Science Award from the American College of Nutrition for his work on cancer. He is a member of the Sigma Xi honor society and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor. Professor Seyfried is also author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press), which has been translated into Chinese and Korean. He has described his research on many podcasts and radio shows and his work is central to the documentary film, The Cancer Revolution. Professor Seyfried has over 200 peer- reviewed publications and a current h-Index of 77. > During our discussion, you’ll discover: (00:02:08) What is cancer (00:11:53) The different theories of cancer (00:25:23) Are mitochondrial transplants a decent therapy for cancer (00:38:49) Early detection cancer testing (00:43:27) Is the rise in cancers an environmental issue (00:52:22) What is the glucose ketone index (01:03:03) Are there issues with doing the ketogenic diet long term The vP life Podcast is brought to you by vitalityPRO , a supplement company based in the UK that provides you with the latest in health, anti-ageing and longevity supplementation. What makes vitalityPRO unique is that it third-party tests every product batch for quality, purity, heavy metals and other contaminants. vitalityPRO’s mission is simple: provide you with confidence in the quality and effectiveness of your longevity supplements that focus on restoring your cellular health. To save on your first order, navigate to the home page and sign up for the newsletter to receive 10% off your first order. Dr Seyfried Publications Home - Thomas Seyfried Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer | Amazon.co.uk Dr Seyfried Pubmed <a href="https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/tho

What if the cancer treatment that works best is the one pharmaceutical companies can't profit from? What if one of the cancer treatments that works best is the one the pharmaceutical companies can't profit from?! Dr. Katie sits down again with Professor Thomas Seyfried to explore why the medical system resists alternative approaches to a disease that claims over 1,700 lives daily in the U.S., and what's actually driving cancer at the cellular level. They reveal a specific therapeutic strategy that targets both fuels cancer cells depend on to survive. Dr. Seyfried explains how cancer isn't the genetic lottery you've been led to believe, it's a metabolic condition with a metabolic solution. You'll learn why your body's normal cells thrive on completely different fuel than cancer cells do, and how a compound called DON (a glutamine antagonist) combined with therapeutic ketosis creates conditions where healthy cells flourish while cancer cells can't survive. Chapters: 00:13:25 – Starving the Tumor 00:16:22 – The Banned Cancer Drug 00:21:03 – Beyond the Keto Diet 00:32:00 – Why Healing Threatens the ‘System’ 00:37:15 – The Genetic Myth Dr. Katie and Dr. Seyfried discuss the practical challenges patients face when trying to find providers who understand this science, why measuring your glucose-ketone index matters more than following any specific meal plan. Dr. Seyfried's research team is seeing remarkable outcomes in advanced cases that conventional medicine has given up on, and he shares exactly what that approach looks like. Listen and learn why the paradigm shift in cancer management isn't just coming, it's already here, waiting for the rest of the world to catch up. Dr. Seyfried: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on Instagram Watch on Youtube DISCLAIMER: The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider. A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health.

​⚠️ IMPORTANT DISCLAIMER: This episode is for informational and entertainment purposes only. The host(s) and guest(s) are NOT financial advisors, attorneys, medical professionals, or licensed experts. You should always consult with a qualified professional before making any financial, legal, or health decisions. Reliance on any information provided in this podcast is solely at your own risk. Is cancer really a genetic disease — or a metabolic one? 🧬 In this episode, Dr. Thomas Seyfried, professor of biology at Boston College and author of Cancer as a Metabolic Disease, breaks down why glucose and glutamine fuel cancer growth and how nutritional ketosis and metabolic therapy can help prevent and manage cancer more effectively. Discover how tracking the Glucose-Ketone Index (GKI), exercising regularly, and targeting cellular metabolism can transform the way we understand cancer treatment. 🚀 If you care about metabolic health, cancer prevention, or functional medicine, this is a must-watch episode. 💡 Key Takeaways ✅Cancer is primarily a metabolic disease, not a genetic one. ✅Glucose and glutamine are the main fuels for cancer cells. ✅A ketogenic diet and GKI monitoring can support cancer management. ✅The press-pulse strategy targets cancer cells through metabolic control. ✅Exercise and mitochondrial health are vital in prevention. ✅Philanthropy fuels innovation in cancer research. 👨‍🔬 About Dr. Thomas Seyfried Dr. Thomas N. Seyfried is a Professor of Biology at Boston College and one of the world’s leading experts on metabolic therapy for cancer. His groundbreaking research challenges the conventional genetic theory of cancer and focuses on how metabolic dysfunction drives tumor growth. He is the author of “Cancer as a Metabolic Disease” — a book that’s changing how the world thinks about cancer treatment and prevention. Connect with Dr. Thomas Seyfried: Website: http://bit.ly/4hwsttS Connect with The Healthy Wealth Experience: 🎙️ Subscribe for weekly episodes 💼 Chris Hall - Redding Financial Advisors 📧 Email: healthywealthexperience.com Listen on: Spotify | Apple Podcasts | YouTube | Your Favorite Platform 🎧 Chapters 00:00 – Introduction to Cancer Research and Metabolism 03:34 – Cancer as a Metabolic Disease 07:49 – The Role of Glucose and Glutamine in Cancer 11:35 – Transitioning to Nutritional Ketosis 17:23 – Challenges in the Medical Establishment 21:28 – Spreading Awareness and Knowledge 27:44 – Targeting Glutamine in Cancer Treatment 33:56 – Developing Comprehensive Treatment Protocols 36:49 – Managing Cancer Effectively 39:16 – The Role of Metabolic Therapy 45:02 – Preventing Cancer Through Mitochondrial Health 50:10 – Advocating for Change in Cancer Treatment 54:35 – Practical Steps for Cancer Prevention 🔗Links to Dr. Thomas Seyfried for further readings Press-pulse: a novel therapeutic strategy for the metabolic management of cancer: http://bit.ly/3LyWMDY Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma: http://bit.ly/43E0pP9 The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer: http://bit.ly/4oj9EwG #CancerResearch #MetabolicHealth #KetogenicDiet #CancerPrevention #MetabolicTherapy #HealthPodcast #DrThomasSeyfried #GlucoseKetoneIndex #NutritionAndCancer #MitochondrialHealth #PressPulseStrategy #CancerAwareness #HealthOptimization #FunctionalMedicine

What if cancer isn't primarily a genetic disease — but a metabolic one? In this groundbreaking conversation, Professor Thomas N. Seyfried, PhD (Boston College), author of Cancer as a Metabolic Disease , joins Ralph W. Moss, PhD and Ben Moss to discuss the Mitochondrial and Metabolic Theory of Cancer — and why it challenges decades of conventional thinking. Dr. Seyfried explains how cancer cells depend on glucose and glutamine as their dual fuel supply — and how cutting off both pathways may be the key to shutting cancer down. He details the role of the Glucose Ketone Index (GKI), nutritional ketosis, and new interest in anti-parasitic drugs like fenbendazole and mebendazole, which appear to target cancer's energy metabolism. This episode explores: Why the somatic mutation theory no longer explains cancer's true origin How mitochondrial dysfunction drives tumor growth The critical role of glucose and glutamine fermentation in sustaining cancer cells Why targeting both fuels together is essential for effective therapy Emerging research on fenbendazole, mebendazole, and DON as tools in metabolic therapy The potential of a paradigm shift in oncology — from genes to metabolism Resources: This Podcast contains many scientific terms. To assist our readers in understanding them, we have created this glossary. The article with links, resources and full transcript can be found here: https://themossreport.com/s5-e13-prof-thomas-seyfried-mitochondrial-metabolic-theory/ Direct link to The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer https://link.springer.com/content/pdf/10.1007/s10863-025-10059-w.pdf In the Journal https://link.springer.com/article/10.1007/s10863-025-10059-w Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis Christos Chinopoulos & Thomas N. Seyfried Paper https://www.tandfonline.com/doi/epdf/10.1177/1759091418818261?needAccess=true (PDF) https://www.tandfonline.com/doi/full/10.1177/1759091418818261 Christos Chinopoulos https://semmelweis.hu/english/2019/09/my-university-dr-christos-chinopoulos-and-the-rppa-facility/ Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma https://pubmed.ncbi.nlm.nih.gov/31149644 Glucose Ketone Index Calculator Post https://pmc.ncbi.nlm.nih.gov/articles/PMC4367849 Spreadsheet with calculator https://pmc.ncbi.nlm.nih.gov/articles/instance/4367849/bin/12986_2015_9_MOESM1_ESM.xlsx Sam Apple - Ravenous <a href= "https://amzn.to/4nr6

Access the FREE Water Fasting Masterclass Now: https://www.katiedeming.com/the-healing-power-of-fasting/ What lifestyle choices can reduce your risk before cancer develops? (Video Re- Release - Watch here: https://youtu.be/fAZ81saCTOA?si=3PipGywmSY5mOlxS ) Dr. Katie Deming sat down with Dr. Thomas Seyfried, professor of biology at Boston College and author of Cancer as a Metabolic Disease. Together, they explore how cancer cells depend on sugar and glutamine for fuel, why the mitochondria, not DNA mutations, may be at the heart of the disease, and what this understanding means for prevention and treatment. Key Highlights: Can dietary changes, fasting, and exercise support treatment once cancer is diagnosed? Why should patients and doctors pay attention to the Glucose Ketone Index (GKI) to measure how the body is fueling itself? What can you do today to reduce your risk of chronic illness? Dr. Seyfried explains the Warburg Effect, the role of dysfunctional mitochondria in cancer growth, and why standard treatments may sometimes work against us by feeding cancer's energy needs. Listen, learn the surprising story of how weight loss, not a new drug, led to dramatic tumor reduction in lab studies. Dr. Thomas Seyfried: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html Join Dr. Katie's 3-Day Guided Fast, for expert support, daily live calls, and a community to fast alongside: Sign-Up Follow Dr. Katie Deming on Instagram Watch on Youtube DISCLAIMER: The Born to Heal Podcast is intended for informational purposes only and is not a substitute for seeking professional medical advice, diagnosis, or treatment. Individual medical histories are unique; therefore, this episode should not be used to diagnose, treat, cure, or prevent any disease without consulting your healthcare provider. A thought-provoking podcast explores cancer through the lens of holistic medicine and functional medicine, discussing causes of cancer, metabolic health, and unconventional approaches like water fasting, fasting and autophagy, and detox, while weighing fasting benefits against chemo side effects and radiation side effects, sharing stories of a cancer survivor navigating chemotherapy, natural medicine, holistic healing, and even spiritual healing on the path toward cancer remission and holistic health.

🎙️ Episode 89: Dr. Thomas Seyfried — Cancer is a Metabolic Disease: How Nutrition Empowers Prevention and Treatment In this groundbreaking episode, Dr. John Barnes welcomes legendary researcher and author Dr. Thomas Seyfried to challenge everything you thought you knew about cancer. Rather than viewing cancer as a genetic destiny, Dr. Seyfried presents compelling evidence that it is, at its core, a metabolic disease —and that gives us the power to fight back. Together, they explore how modern lifestyles and processed nutrition disrupt our evolutionary biology, contributing to mitochondrial dysfunction and the onset of chronic disease—including cancer. More importantly, they reveal how targeted dietary strategies like ketogenic therapy, fasting, and carbohydrate restriction can support healthy cells, starve cancer cells, and restore the body’s natural resilience. Highlights include: ✅ The Warburg effect and why damaged mitochondria—not mutated genes—may be the true root of cancer ✅ How nutrition can be used not just to prevent, but to treat cancer alongside other therapies ✅ The critical role of glucose and glutamine in tumor growth—and how to cut off the fuel supply ✅ Empowering patients and practitioners to take action through metabolic health strategies This conversation is a masterclass in metabolic medicine and a beacon of hope for anyone touched by cancer. Whether you're a patient, provider, or simply health-curious, this episode will equip you with science-backed tools to make Life Possible —even in the face of cancer. If you found this information helpful, please consider donating to support Professor Seyfried’s cancer metabolic therapy research. This can be done in the below ways: Professor Seyfried’s Biology Department - https://g2ul0.app.link/qqiEVKOufOb Foundation for Cancer Metabolic Therapies - https://g2ul0.app.link/urNJEBUufOb A message from Professor Seyfried: “Please consider a donation ONLY if the information helps you. Your donation will keep our work moving forward.”

Episode 2672 - BEST OF: Vinnie Tortorich welcomes Dr. Thomas Seyfried and they discuss metabolic dysfunction, glucose, glutamine, and cancer therapies. https://vinnietortorich.com/2025/07/glucose-glutamine-cancer-dr-thomas-seyfried-episode-2672 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Glucose, Glutamine, and Cancer Vinnie explains why he recommends listening to Dr. Thomas Seyfried. (2:00) Vinnie has been in remission and avoided chemo for 17 years by leading a ketogenic lifestyle. There are all kinds of side effects from chemotherapy, even though it can save people. There have been several theories of disease. (8:00) NCI states that cancer is a genetic disease of dysregulated cell growth, called the somatic mutation theory. Another theory suggests that damage to organelles can cause mutations in cells, or that mutations may have a mitochondrial metabolic origin. The treatment of cancer as a metabolic disease also allows people to participate in the management of their disorder. He explains the importance of oxygen and energy and how they affect the cells. (11:00) This is known as the mitochondrial metabolic theory of cancer. Dr. Seyfried explains some fascinating experiments and theories. (14:00) Once there is an agreement on the mitochondrial metabolic theory, treatment for cancers could be much less toxic and more manageable. (17:00) Metabolically treating cancer can help because even if there is recurrence, it can often be treated with fewer chemicals. (20:00) The idea is to reduce or eliminate the cancer through diet and medication that target the fermentation metabolism. Glutamine is an amino acid and has many uses in the body. (22:30) Dr. Seyfried explains the press-pulse therapeutic strategy. The Glucose Ketone Index What kind of diet and supplementation can help those who may have cancer? (27:30) The Glucose Ketone Index (GKI) calculator and its function are explained. How the GKI happens varies per person, but if you can keep the GKI measurement at 2.0 mmol or below, you can put pressure on the tumor cells. (29:00) Each person is their own experiment, but low-carb is beneficial as it keeps your ketones active. Vinnie asks Dr. Seyfried to explain ketone measurements and monitors. (32:30) They discuss genetics, such as the BRCA1 mutation. (36:00) They discuss the frustration of some doctors' approaches to other diseases. (40:00) Type 2 diabetes has replaced smoking as the number one risk factor for cancer! (43:15) They discuss the challenges of today's diet and lifestyle. (46:00) Low-cost and convenience foods are taking their toll on society's health. Type 2 diabetes is a diet and lifestyle issue. Give people the opportunity to make their own choices. Many doctors need to be re-educated, and people need to know all their options. (50:30) Processed food and glucose are a highly addictive force on the brain. (51:00) Dr. Seyfried is a professor who shares information about and is developing a protocol, which he hopes will be available soon. His website is: https://tomseyfried.com More News If you are interested in the NSNG® VIP group is currently closed for registration, but you can get on the wait list -https://vinnietortorich.com/vip/ Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Make sure you watch, rate, and review it! Eat Happy Italian, Anna's next cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, website, and Substack–they will spice up your day! https://annavocino.substack.com/ Don't forget you can invest in Anna's Eat Happy Kitchen through StartEngine. Details are at Eat Happy Kitchen. https://eathappykitchen.com/ PURCHASE DIRTY

Thomas N. Seyfried is Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England and holds a Master's degree in Genetics from Illinois State University, Normal, IL. He was a Postdoctoral Fellow & Assistant Professor in the Neurology Dept. at the Yale University School of Medicine. He presently serves on several editorial boards, including those for Nutrition & Metabolism , Neurochemical Research , the Journal of Lipid Research , and ASN Neuro, where he is a Senior Editor. Dr. Seyfried has over 200 peer reviewed publications and is author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press). His book was recently translated into Chinese and is now under contract for translation into Turkish. His full list of peer-reviewed publications can be found on PubMed. Dr. Seyfried’s PubMed publications: https://pubmed.ncbi.nlm.nih.gov/?term=Thomas+Seyfried Dr. Seyfried’s YouTube channel: https://youtube.com/@talkingcancer-u4k?si=lev6fert7fiIAfti Dr. Seyfried’s X account: https://x.com/tnseyfried Dr. Seyfried’s Instagram account: https://www.instagram.com/thomasseyfriedbc/ Link to organization to which people can donate to support Dr. Seyfried’s work: https://www.foundationformetaboliccancertherapies.com/index.php?option=com_jdonation&view=donation&campaign_id=1&Itemid=104 Show Notes In this episode, we cover the following: Cancer is driven by defective energy metabolism, not genetic mutations. All major cancers share the same core problem: dysfunctional mitochondria. The Warburg Effect shows cancer cells use fermentation even in the presence of oxygen. Cancer triggers are diverse but all link to mitochondrial failure (the oncogenic paradox). Oxygen consumed by cancer cells is not used for efficient energy production. Ketogenic diets and glutamine targeting can starve cancer cells. Metabolic therapy applies broadly across most cancer types. Seed oils likely contribute to mitochondrial damage and chronic disease. We have significant control over cancer risk through diet and lifestyle. The idea that meat causes cancer is likely overstated and not well-supported. How cancer spreads. Rising cancer rates in young people. Future cancer management should shift toward metabolic therapies over genetic treatments. Seyfried encourages future doctors to question dogma and focus on energy metabolism. [Disclaimer: All health and nutritional information on this podcast should not take place of medical or professional advice. Although I am a medical doctor, I am not your healthcare provider. This episode is for informational and educational purposes only and should not substitute the advice from your healthcare professional. Always consult with your physician / healthcare provider prior to making any exercise, dietary, medical, or lifestyle decisions. Those who do not seek counsel from the appropriate healthcare provider assume the liability of any injury / adverse events which may occur. Do not follow the advice in this episode if you do not wish to be bound by this disclaimer.]

In this compelling episode, Dr. Vera Tarman interviews Dr. Thomas Seyfried, a pioneer in the field of cancer metabolism. Dr. Seyfried challenges the mainstream view of cancer as a genetic disease and presents strong evidence that cancer is fundamentally a mitochondrial metabolic disorder. Dr. Thomas N. Seyfried is a distinguished American biologist and professor at Boston College, renowned for his pioneering work in cancer metabolism. With a Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, and postdoctoral training in neurochemistry at Yale University School of Medicine, Dr. Seyfried has dedicated his career to exploring the metabolic underpinnings of cancer and other neurological diseases. Dr. Seyfried is best known for his groundbreaking book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (2012), where he presents compelling evidence that cancer is primarily a mitochondrial metabolic disorder rather than a genetic one. This perspective builds upon the early 20th-century findings of Otto Warburg, who observed that cancer cells rely heavily on fermentation for energy production, even in the presence of oxygen—a phenomenon known as the Warburg effect. Dr. Seyfried's research suggests that targeting cancer's metabolic dependencies, such as glucose and glutamine, through dietary interventions like the ketogenic diet, could offer non-toxic therapeutic strategies. We explore: How cancer cells fuel themselves differently from healthy cells The connection between sugar, ultra-processed foods (UPFs), and cancer growth The Warburg Effect and the roles of glucose and glutamine in tumor development Whether refined sugar is carcinogenic like tobacco Why Dr. Seyfried believes ketogenic diets and caloric restriction can be powerful cancer therapies How his views align with metabolic psychiatry (Dr. Chris Palmer's Brain Energy) The controversial yet promising approach of "press-pulse" therapy The potential for preventing cancer through dietary change Follow: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.html https://tomseyfried.com The content of our show is educational only. It does not supplement or supersede your healthcare provider's professional relationship and direction. Always seek the advice of your physician or other qualified mental health providers with any questions you may have regarding a medical condition, substance use disorder, or mental health concern.

In this episode, Dr. Thomas Seyfried, a leading metabolic cancer researcher and professor at Boston College, discusses the paradigm shift in cancer research with Dr. Hartman. Dr. Seyfried emphasizes the transition from viewing cancer as a genetic disease to understanding it as a metabolic disorder, highlighting mitochondrial dysfunction and fermentation in cancer cell energy production. They explore the implications of this perspective for treatment, including metabolic therapies and dietary strategies. Dr. Seyfried shares case studies and advocates for personalized treatment plans. The episode underscores the importance of metabolic approaches in improving cancer outcomes and calls for greater acceptance within the medical community. Resources & Links: 🌐 Dr. Thomas Seyfried – Boston College Faculty Page: bc.edu 📘 Book – Cancer as a Metabolic Disease by Dr. Thomas Seyfried 🌐 Dr. Aaron Hartman – Richmond Functional Medicine: richmondfunctionalmedicine.com 🌐 LinkedIn – Dr. Aaron Hartman: Connect Here 📹 YouTube Channel – Richmond Functional Medicine: Watch Here

Send us Fan Mail Short Summary: Cancer’s metabolic roots with Dr. Thomas Seyfried. About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years. Note: Podcast episodes are fully available on the M&M Substack and YouTube . Transcript and other information on Substack. Episode Summary: Dr. Thomas Seyfried discusses the mitochondrial metabolic theory of cancer, challenging the dominant somatic mutation theory. He explores how cancer cells rely on fermentation due to defective oxidative phosphorylation, drawing on Otto Warburg’s work. Seyfried explains how ketogenic diets and nutritional ketosis can starve cancer cells by limiting glucose and glutamine, while sharing evidence from nuclear transfer experiments and clinical studies. The conversation also covers environmental factors driving cancer and the importance of metabolic flexibility for prevention. Key Takeaways: Cancer is characterized by dysregulated cell growth, but Seyfried argues it stems from mitochondrial dysfunction, not just genetic mutations. Cancer cells ferment glucose & glutamine, unable to use fatty acids or ketones, making ketogenic diets a potential therapeutic tool. Nuclear transfer experiments show cancer traits reside in the cytoplasm, not the nucleus, challenging the somatic mutation theory. Environmental factors like processed foods, stress, and poor sleep disrupt mitochondrial function, increasing cancer risk. Seyfried’s glucose-ketone index helps monitor metabolic states to manage cancer & chronic diseases. Cancer rates are rising in younger people, possibly due to obesity, inflammation, and environmental toxins. Metabolic flexibility, cycling between ketosis and carb-based states, may mimic ancestral patterns and reduce chronic disease risk. Related episode: M&M #215 : Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti *Not medical advice. Support the show Health Products by M&M Partners: AquaTru : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. OmegaQuant : At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M. SiPhox Health : Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off. KetoCitra —Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) SporesMD : Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. For all the ways you can support my efforts