David SinclairEvery podcast appearance, updated as new ones drop

In this groundbreaking conversation, Professor of Genetics and longevity scientist, Dr. David Sinclair, A.O., Ph.D., joins Sarah Grynberg to unpack the future of human aging, the science of longevity, and how we live today impacts how we age tomorrow. From reversing blindness in mice to exploring treatments that could one day delay menopause and extend healthy human life, this episode will completely change the way you think about your body, your health, and your future. But beyond the science, this is also a deeply human conversation about purpose, suffering, love, family, and what it truly means to live a great life. In this episode, you will learn: Why aging may actually be reversible The daily habits accelerating aging in your body right now How stress, loneliness, and cortisol could impact longevity The real science behind supplements like NMN, resveratrol, and NAD boosters Why exercise, sleep, and relationships matter more than you think What Dr. Sinclair believes is coming in the next 10 years of medicine How scientists are working to reverse female infertility and delay menopause The surprising reason your “biological age” may be younger or older than your real age Why suffering through disease and decline should not be considered “normal aging” The philosophy and mindset Dr. Sinclair lives by every day This episode is a powerful reminder that longevity is not just about living longer… it’s about living better. To find out more about Dr Sinclair's work: Website: lifespan.com and friendsofsinclairlab.org Book: Lifespan: Why We Age—and Why We Don’t Have To Podcast: Lifespan with Dr. David Sinclair on Spotify, Apple, YouTube Purchase Sarah's book: Living A Life Of Greatness here. To purchase Living A Life of Greatness outside Australia here or here. Watch A Life of Greatness Episodes On Youtube here. Sign up for Sarah’s newsletter (Greatness Guide) here. Purchase Sarah's Meditations here . Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/ Facebook: facebook.com/sarahgrynberg Twitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

Welcome back to Impact Theory with Tom Bilyeu . In this electrifying continuation, Tom Bilyeu dives deep with world-renowned aging researcher Dr Sinclair to explore the cutting edge of anti-aging science and regenerative medicine. Prepare for a mind-bending journey through lab-grown “mini brains,” the ethics of creating organs from scratch, and the real-world implications of reversing aging—in everything from skin and hair to the human brain and spinal cord. You’ll hear insights on the latest advances in using AI to develop longevity drugs, the surprising possibilities for reversing age-related infertility, and how upcoming clinical trials may soon change the way we think about disease, aging, and human potential. Plus, Dr Sinclair shares his personal health protocol and practical strategies for extending your lifespan today, all while tackling big questions about the future—from living to 1000 years, to the cautionary tales and optimism inherent in this rapidly evolving field. Get ready for a conversation that bridges science fiction and reality as Tom Bilyeu and Dr Sinclair unpack what it means to truly disrupt aging. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER : https://tombilyeu.com/zero-to-founder?utm_campaign=Podcast%20Offer&utm_source=podca[%E2%80%A6]d%20end%20of%20show&utm_content=podcast%20ad%20end%20of%20show SCALING a business: see if you qualify here. : https://tombilyeu.com/call Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. : https://tombilyeu.com/ ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu’s Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ***********

You don’t understand aging. You’ve been lied to about what’s possible for the human body. You think the march toward old age and disease is inevitable, and that genetics are your destiny. The reality is, we’re living through the greatest turning point in the history of human health—and most people have absolutely no idea just how fast it’s all happening. What if I told you that not only can we slow the aging process, but that it’s starting to look like we can actually reverse it? Thanks to the exponential power of AI and the most cutting-edge biotechnology, what used to take centuries and cost billions is now possible in months, for a fraction of the price. Today on Impact Theory, we are joined by a true pioneer who’s redefining what it means to get old—someone at the intersection of AI, biology, and longevity: researcher, Harvard professor, and world-renowned expert on aging, Dr. Sinclair. Strap in, because this episode is packed with groundbreaking science, jaw-dropping experiments, and a vision for the future that will challenge everything you think you know about what it means to stay young. Let’s dive in. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER : https://tombilyeu.com/zero-to-founder?utm_campaign=Podcast%20Offer&utm_source=podca[%E2%80%A6]d%20end%20of%20show&utm_content=podcast%20ad%20end%20of%20show SCALING a business: see if you qualify here. : https://tombilyeu.com/call Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. : https://tombilyeu.com/ ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu’s Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************

Scientist and Harvard professor Dr. David Sinclair, A.O., Ph.D., reveals his latest research on how to reverse ageing, insights into vitamins and supplements, why DNA is not your destiny, and the first clinical trials to reverse human ageing and blindness! Dr. David Sinclair is a world-renowned Professor of Genetics at Harvard Medical School and the leading authority on longevity science. He is Founder of Lifespan.com and multiple biotechnology companies, Co-Chief Editor of the journal Ageing, and bestselling author of ‘Lifespan: Why We Age - And Why We Don’t Have To’. Dr. Sinclair explains: ◼️The “Information Theory of Aging” that regards ageing as a treatable disease ◼️Advances in resetting biological age using cellular “backup copies” ◼️His specific supplement stack for longevity ◼️Why fasting and “good stress” are science-based longevity strategies ◼️How his lab’s gene therapy is being used to restore eyesight and reverse blindness Enjoyed the episode? Share this link and earn points for every referral - redeem them for exclusive prizes: https://doac-perks.com Research document: https://docs.google.com/document/u/0/d/1sarDR85LvkK5hv7HMN_UUDvHO9MIi9bNPhLyIRZQ9vg/edit Follow David: Lifespan - https://lifespan.com/ Instagram - https://linkly.link/2ajhU Podcast - https://linkly.link/2aji0 YouTube - https://link.thediaryofaceo.com/AiIza5B The Sinclair Lab - https://linkly.link/2ajhX You can purchase David’s book, ‘Lifespan: Why We Age-and Why We Don't Have To’, here: https://linkly.lin

Essentials_ The Biology of Slowing & Reversing Aging _ Dr. David Sinclair

Bạn có thể xem phiên bản video của podcast tại: https://youtu.be/dOD1_j3bf-8 Video này chúng ta sẽ tìm hiểu về việc làm thế nào để làm chậm quá trình lão hóa và kéo dài tuổi thọ thông qua các nghiên cứu của tiến sĩ David Sinclair. Bất chấp những quan điểm truyền thống đã được thừa nhận trong suốt lịch sử, rằng lão hóa là điều tất yếu của cuộc sống, David Sinclair đã đưa ra một lý thuyết táo bạo có thể thay đổi cách bạn nghĩ về lý do tạị sao bạn già đi: Ông nói rằng: “ Lão hóa là một căn bệnh, và căn bệnh đó có thể chữa được ”. Bằng các phương pháp y tế và những thay đổi đơn giản về lối sống của mình, chúng ta có thể đánh thức các gen trường thọ - là hậu duệ của một mạch sống sót cổ xưa để đảo ngược quá trình lão hóa, giúp chúng ta sống trẻ hơn và khỏe mạnh hơn trong thời gian dài hơn. 0:00 David Sinclair: Lão hóa là một căn bệnh có thể chữa được 1:15 Sách: Lifespan: Why We Age – and Why We Don't Have To 3:15 Tại sao con người lại già đi?: Bắt đầu từ nguồn gốc sự sống 7:41 Lão hóa là do mất thông tin (Loss of Information) 8:55 Thông tin di truyền mã hóa trong DNA 9:37 Thông tin biểu sinh (Epigenetic Information -Epigenome) 12:23 Làm thế nào để trì hoãn lão hóa 13:52 1- Ăn ít hơn 17:20 2- Chế độ ăn giàu thực vật, hạn chế protein từ động vật 19:12 3- Tập thể dục nhiều hơn, đổ mồ hôi nhiều hơn 20:54 4- Tiếp xúc với nhiệt độ lạnh/ nóng 22:29 5- Hạn chế tác nhân gây tổn thương DNA 23:37 6- Lão hóa là một căn bệnh, có cách nào chữa khỏi? ☘ Những nội dung trong video này cần rất nhiều thời gian để nghiên cứu, viết kịch bản, thu âm và chỉnh sửa video... Nếu bạn thấy nội dung của mình hữu ích, bạn có thể cân nhắc đóng góp cho sự phát triển của kênh ngay hôm nay nhé. Cảm ơn vì sự cho đi hào phóng của bạn ❤ 🎁 Bank: 7807 1044 - LE THI NGA - VPBank (Ngân hàng Việt Nam Thịnh Vượng) Đăng ký kênh Youtube: Inner World Podcast: youtube.com/@Innerworld.podcast?sub_confirmation=1

In this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking research on the role of epigenetic changes in aging and the potential to reverse this process. He explains how lifestyle factors, such as diet and exercise, can greatly impact our longevity, and highlights the importance of regularly monitoring health markers like blood glucose and cholesterol. Dr. Sinclair emphasizes the power of technology, including blood tests and personalized health tracking, to help individuals live healthier, longer lives. The conversation also dives into cutting-edge research on longevity drugs and therapies, including gene therapy and reprogramming cells to a younger state. Dr. Sinclair discusses the promising future of treatments aimed at reversing aging and improving the quality of life well into old age. Episode highlights: Introduction: 00:00:00 Why have you decided to be a scientist and not a painter: 00:02:40 What is the difference between healthspan and lifespan: 00:06:00 Can we extend our lifespan: 00:07:10 What should you do to increase your healthspan: 00:09:40 How can we increase our lifespan: 00:14:45 Upcoming Season of David’s Podcast: 00:19:40 GLP-1 as a longevity drug: 00:21:40 The information theory of aging: 00:25:40 How are cells and organisms reprogrammed in the lab: 00:30:10 What are the future opportunities in cell reprogramming: 00:32:50 What is the effect of reprogramming on cancer cells: 00:36:00 What is the effect of reprogramming on senescent cells: 00:38:50 David's top tip for healthspan: 00:42:10 Epigenetic Changes Drive the Aging Process David Sinclair explains that aging is not just wear and tear on the body, but a loss of information within cells. This concept, known as epigenetic aging, involves cells losing their ability to read the right genes at the right time. As cells age, they lose their identity, leading to aging and age-related diseases. The exciting part of this discovery is that these changes may be reversible. Dr. Sinclair’s research focuses on reprogramming cells to restore their youthful function, potentially turning back the biological clock and extending healthspan and lifespan. Lifestyle Choices Are Key to Longevity David Sinclair emphasizes that simple lifestyle choices—like diet, exercise, and regular health monitoring—can have a profound impact on both healthspan and lifespan. He stresses the importance of moving regularly, avoiding processed foods, and maintaining a healthy weight. These actions, along with monitoring key biomarkers such as glucose and cholesterol, are crucial in delaying the onset of age-related diseases. Sinclair’s father, who at 85 is in excellent health, serves as a prime example of how these practices can help people live healthier, longer lives. We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast

Have you listened to the FULL EPISODE yet? "We can actually grow little brains in the dish too... And we can age them forwards, make them older... And then we reverse it." - Dr. David Sinclair Prepare for a journey into the cutting edge of longevity science as Lewis sits down with world-renowned geneticist and aging expert, Dr. David Sinclair. In this electrifying episode, Sinclair unveils the revolutionary concept that aging isn't just a natural process - it's a disease we can potentially cure. From the secrets of 'longevity genes' to the mind-bending ability to grow and reverse-age human brain cells in a lab, Sinclair's insights will challenge everything you thought you knew about getting older. But this isn't just about extending life - it's about reimagining what it means to be human. Sinclair dives deep into the ethical implications and practical possibilities of his work, offering a tantalizing glimpse into a future where age-related diseases could become a thing of the past. Whether you're a science enthusiast or simply someone who wants to live their best life for as long as possible, this episode is a must-listen. Tune in now and discover how the fountain of youth might just be hiding in your own DNA! Sign up for the Greatness newsletter!

Have you listened to the FULL EPISODE yet? "The way to think of this is, if you've ever heard of the epigenome, these are the control systems that control our DNA. It turns out that that system you can measure. It's chemicals on your DNA that change over time predictably. And we've just developed a way to measure that 100 times cheaper than it was before. And I'm gonna bring this test to the public so that people can test their biological age." - Dr. David Sinclair In this fascinating episode, renowned longevity expert Dr. David Sinclair reveals groundbreaking insights into the science of aging and how our lifestyle choices directly impact our biological age. Dr. Sinclair introduces the concept of biological age versus chronological age, explaining how advanced testing methods can now determine how quickly or slowly our bodies are aging at a cellular level. Dr. Sinclair shares his personal experience with optimizing his own health, discussing how he's managed to maintain a biological age significantly younger than his chronological age. He details the development of new, more accessible testing methods, including a cheek swab DNA methylation test, that could revolutionize how we monitor and manage our health. Throughout the conversation, Dr. Sinclair emphasizes the importance of understanding the impact of our daily habits - from smoking and alcohol consumption to exercise and diet - on our biological age. His insights offer listeners a roadmap to potentially slow down or even reverse their aging process, providing hope and practical strategies for those seeking to extend their healthspan and lifespan. Sign up for the Greatness newsletter!

Dr. David Sinclair explains the Sinclair Method, also known as pharmacological extinction, for treating alcoholism. The method involves the use of Naltrexone to block endorphins released when drinking alcohol, weakening the neural pathways associated with alcohol consumption. Extinction is the process of eliminating behaviors that no longer provide reinforcement. The method has been successful in about 80% of alcoholics, but not all types of alcoholism respond to this treatment. Highlights 🍺 Alcohol addiction is a learned behavior reinforced by endorphins released in the brain. 🧬 Genetic factors can influence the strength of the addiction. 🛑 Alcoholics reach a point where they cannot say no to alcohol. 🧠 The brain has a process called extinction to eliminate behaviors that no longer provide reinforcement. 🐀 Rats take about five days to become obsessed with drinking alcohol. 💊 The Sinclair Method using Naltrexone has been successful in about 80% of alcoholics. ❌ Not all types of alcoholism respond to this treatment. About Thrive Alcohol Recovery Thrive Alcohol Recovery is a worldwide online alcohol treatment program that uses a neuroscience-based approach to treat alcohol addiction with a clinically-proven 78% success rate. This treatment is called The Sinclair Method and uses the medication naltrexone to help individuals unlearn alcohol use disorder over time. Thrive delivers this treatment privately and 100% online through a computer or mobile app – making it easier than ever for someone to find freedom from problem drinking so they can live their best life. About Katie Lain Katie Lain struggled with alcohol use disorder for nearly ten years until she stumbled upon The Sinclair Method. She couldn’t believe how effective the treatment was as it truly allowed her to become a moderate “normal drinker” – yet somehow, most people hadn’t even heard about it before. Katie Lain’s personal success with The Sinclair Method has inspired her to be a lifelong advocate for this method. Today, Katie is "accidentally" alcohol-free as she unexpectedly lost interest in drinking, thanks to this treatment. Now she advocates for and supports others through this wildly effective (yet unknown) treatment for alcohol use disorder. *Links* https://www.thrivealcoholrecovery.com/ https://tiktok.com/@thrivealcoholrecovery https://youtube.com/@thrivealcoholrecovery/ https://www.instagram.com/thrivealcoholrecovery/ https://www.facebook.com/groups/thrivewiththesinclairmethod https://www.linkedin.com/company/thrive-alcohol-recovery/ https://twitter.com/thrivewithtsm/

A Note from James:I particularly want to reverse my aging. I'm not concerned about being able to run a mile or anything like that; I just want to reverse the aging of my brain. I feel there's a definite difference between my brain now and when I was younger. By the way, culturally, we acknowledge that the brain ages. Not only medically, but culturally, you have to adapt to being the wise older person rather than the sharp young person.We had a great conversation with Arthur Brooks about this. He wrote an excellent book, which I can't recommend enough, called "From Strength to Strength." That podcast with Arthur Brooks changed my life in how I view my brain aging. Additionally, several podcasts with David Sinclair about the aging process have also been life-changing.I have used the supplements he recommended and made the lifestyle changes he suggested back in 2019. David has conducted a lot of research in the five years since his book "Lifespan" was released, and I wanted to see what the current state of his research was. So, he came on the podcast.I'm very grateful; he doesn't do many podcasts. He shared some incredible discoveries and new information, giving me real insight. We discussed everything related to what he's doing in anti-aging and what he's discovered since the last time I had him on. At the special request of our listeners, I also asked him about testosterone.Towards the end of the podcast, I asked him about that, and his answer was very interesting. Here's David.Episode Description:Today, James discusses personal motivations for wanting to reverse aging, specifically targeting brain aging. The conversation moves into the broader cultural and scientific understandings of aging, touching on insights from Arthur Brooks and David Sinclair's research. Sinclair's work on anti-aging, including lifestyle changes and supplement use recommended by him, is highlighted, mentioning his book 'Lifespan' and the progress in his research over the past five years. Key discussions include the information theory of aging, the role of DNA and epigenetics in aging, and the concept of age reversal through maintaining or restoring the epigenome's integrity. The episode covers the potential of using Yamanaka factors for age reversal, the challenges in translating these findings from mice to humans, and regulatory considerations for human trials. Sinclair also touches on his ongoing work in developing chemical cocktails for age reversal, comparing lifestyle changes to these scientific advances. Episode Summary:00:00 The Quest for Age Reversal: Personal Motivations and Influential Conversations01:11 Diving Deep into David Sinclair's Research on Anti-Aging02:24 Exploring the Information Theory of Aging and DNA's Role04:30 The Potential of Epigenetics in Reversing Aging07:14 The Challenges and Ethics of Age Reversal Technologies09:01 The Future of Anti-Aging: From Gene Therapy to Accessible Pills10:53 Debunking Myths and Addressing Controversies in Anti-Aging

Join hosts Chuck Warren and Sam Stone this week on Breaking Battlegrounds for a dynamic lineup of discussions. Our first guest, Governor Joe Lombardo, gives an exclusive update on his journey as Nevada's Governor and shares his perspective on the state's progress and his vision for the road ahead. Later in the show, we shift gears to explore the complex world of technology with David Sinclair. Sinclair delves into the intricacies of data gathering and behavioral manipulation by tech giants. Gain a deeper understanding of how these companies collect and leverage user data. Concluding the episode, Rachel Walden, Mesa Public Schools Governing Board Member, brings a crucial dialogue on school safety to the forefront. Gain insight into the latest agreement in Mesa, AZ, where a significant step has been taken to enhance student safety. Every junior high and high school campus now benefits from the presence of school safety resource officers, fostering a secure learning environment. _ Connect with us: www.breakingbattlegrounds.vote Twitter: www.twitter.com/Breaking_Battle Facebook: www.facebook.com/breakingbattlegrounds Instagram: www.instagram.com/breakingbattlegrounds LinkedIn: www.linkedin.com/company/breakingbattlegrounds - Governor Joe Lombardo Born in Japan in a military family, Governor Joe Lombardo spent his childhood growing up across the world, until his father was stationed at Nellis Air Force Base and his family put down roots in Las Vegas. Governor Lombardo attended Rancho High School in North Las Vegas, before going on to attend the University of Nevada, Las Vegas, where he earned his Bachelor of Science degree. After graduating, he served in the United States Army and in the Nevada National Guard. Following his military service, Governor Lombardo joined the Las Vegas Metropolitan Police Department (LVMPD), where he quickly rose through the ranks and served on nearly every level of LVMPD, from detective to assistant sheriff. While serving at LVMPD, Governor Lombardo earned his Master of Science in Crisis Management from the University of Nevada, Las Vegas in 2006. After 26 years on the force, Governor Lombardo was elected as Sheriff of Clark County in 2014 and re-elected in 2018. As the sheriff of Nevada's largest county, he oversaw a $1.3 billion dollar budget, 6,000 employees, and LVMPD's efforts to protect millions of Clark County residents and visitors each day. Governor Lombardo was elected as the 31st Governor of Nevada in November 2022 and sworn into office in January 2023. Governor Lombardo is focused on diversifying and revitalizing Nevada's economy, restoring law and order in communities across the state, and bringing excellence, school choice, and accountability to Nevada's education system. More important to him than anything, Governor Lombardo is a devoted husband to First Lady Donna Lombardo, a dedicated father to his daughter Morgan, stepdaughter Lacey, stepson Jackson, and a grandfather to his 1-year-old grandson Teddy - David Sinclair is the founder and CEO of 4FreedomMobile . A secure mobile service platform that provides secure, unlimited talk, text and high-speed data worldwide, while preventing tech companies, network operators, and others from tracking users' location, identity, communications, internet acti

In this episode, filmed during Abundance360 , Peter and David discuss David’s groundbreaking research on reversing aging through epigenetic changes, emphasizing that aging is not just damage to the body but a loss of information. They talk about age reversal as a possibility,rejuvenating brains and regaining lost memories. 03:06 | Reversing Human Aging: Possible? 22:28 | Rejuvenating Brains With Science 38:48 |Reversing Aging Through Diet David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller , David has co-founded several biotech companies, a science publication called Aging , and is an inventor of 35 patents Read Sinclair’s latest study, Chemically Induced Reprogramming to Reverse Cellular Aging _____________ Get Peter's new Longevity Practices book for free: https://www.diamandis.com/longevity Seed’s DS-01® Daily Synbiotic – a 2-in-1 probiotic and prebiotic that supports digestive health, gut immunity, skin health, heart health, and more. Try Seed’s DS-01® Daily Synbiotic , and make sure to use the code MOONSHOTS at checkout to get a 25% discount. _____________ I send weekly emails with the latest insights and trends on today’s and tomorrow’s exponential technologies. Stay ahead of the curve, and sign up now: Tech Blog _____________ Connect With Peter: Twitter Instagram Youtube Moonshots and Mindsets Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to the "One Meal A Day with David Sinclair" podcast, where we explore groundbreaking research and discoveries in the field of aging and health. Join us as we dive into fascinating conversations with renowned scientist David Sinclair, known for his pioneering work in the molecular biology of aging. In each episode, David Sinclair delves into cutting-edge topics and shares his insights on how we can live healthier, longer lives. From exploring the latest breakthroughs in anti-aging science to discussing practical lifestyle strategies, this podcast is your go-to resource for unlocking the secrets of longevity. With his warm and engaging style, David Sinclair invites experts from various disciplines to join him in thought-provoking discussions. Together, they explore the potential of emerging technologies, delve into the science behind nutrition and exercise, and examine the impact of genetics and epigenetics on the aging process. Whether you're a lifelong health enthusiast, a curious individual seeking to understand the science of aging, or someone looking for practical tips to optimize your well-being, this podcast offers valuable insights and actionable advice. Join us on this enlightening journey as we unravel the mysteries of aging and discover how we can age well with grace and vitality. Get ready to challenge conventional wisdom, embrace innovative ideas, and take control of your health. Tune in to the "One Meal A Day with David Sinclair" podcast and embark on a transformative exploration of the science of longevity. Note: This podcast is for informational purposes only and should not be considered as medical advice. Please consult with a healthcare professional before making any changes to your lifestyle or implementing any recommendations discussed in the episodes.

David Sinclair is a professor of genetics at Harvard Medical School and the founder of the Sinclair Lab. He’s the author of the bestselling book Lifespan: Why We Age—and Why We Don’t Have To , as well as a founder of several biotech companies. Auren and David discuss the potential to expand the average human lifespan by decades. David challenges traditional notions of aging and emphasizes the need to embrace new technologies. They also discuss the benefits and drawbacks of common anti-aging practices like interval training, fasting, and stress reduction. David shares his thoughts on what longevity medicines and supplements are most beneficial, and how to talk to your doctor about them. He breaks down which health metrics to monitor in treating and preventing aging. Overall, David offers an incredibly optimistic vision for what the future of aging could look like, and the science it will take to get there. World of DaaS is brought to you by SafeGraph & Flex Capital . For more episodes, visit safegraph.com/podcasts . You can find Auren Hoffman on Twitter at @auren and David Sinclair on Twitter at @davidasinclair

What causes aging? In a paper published last month, Dr. David Sinclair, Professor in the Department of Genetics at Harvard Medical School, reports that he and his co-authors have found the answer. Harnessing this knowledge, Dr. Sinclair was able to reverse this process, making mice younger, according to the study published in the journal Cell . I talked with Dr. Sinclair about his new study for the latest episode of Making Sense of Science. He said that turning back the clock on mouse age through what’s called epigenetic reprogramming – and understanding why animals get older in the first place – are key steps toward finding therapies for healthier aging in humans. We also talked about questions that have been raised about the research by Dr. Charles Brenner, Department Chair at City of Hope National Medical Center, and Dr. James Timmons, Senior Fellow at Queens Mary University. Show links: Dr. Sinclair's paper , published last month in Cell . Recent pre-print paper - not yet peer reviewed - showing that mice treated with Yamanaka factors lived 9% longer than the control group. Dr. Sinclair's podcast . Previous research on aging and DNA mutations, noted in a critique by Dr. Charles Brenner. Leaps.org podcast with Dr. Brenner. Dr. Sinclair's book, Lifespan . Making Sense of Science features interviews with leading medical and scientific experts about the latest developments in health innovation and the big ethical and social questions they raise. The podcast is hosted by science journalist Matt Fuchs

Descarga GRATIS La Guia de 25 Creencias Empoderadoras: https://bit.ly/3M4s2qC ¿Estamos más cerca de volvernos biológicamente inmortales? ¿Qué te esforzarías por hacer o qué soñarías si pudieras extender tu vida a 150 años? Hasta hace poco, la idea de la longevidad se sentía más como llegar a los 90 y posiblemente a los 100 en el mejor de los casos, y si logra lograr ese objetivo, lo mejor y lo esperado sería una alta calidad de vida. Pero, ¿y si pudieras extender tu vida útil incluso 10 años? Asegurarse de que esos años sean emocionantes y significativos sería una prioridad. El Dr. David Sinclair, un genetista de renombre mundial, se une a Tom en este episodio para desglosar exactamente por qué envejecemos a nivel celular y qué se está volviendo posible ahora en términos de ralentizar nuestro reloj biológico e incluso posiblemente revertirlo, nuestra edad biológica. Si desea saber qué puede hacer para comenzar a mejorar la calidad de vida de su envejecimiento y mantenerse joven por más tiempo, este episodio es para usted, y querrá consultar el podcast más reciente del Dr. David Sinclair, Lifespan (enlace a continuación). CAPITULOS 0:00 | Introducción a David Sinclair 0:28 | Por qué envejecemos 9:40 | Lo que va mal con el envejecimiento 23:44 | Cómo revertir el envejecimiento 37:35 | Enfrentar la adversidad 45:37 | Cómo funciona la metformina 55:02 | Estilo de vida para la longevidad CITAS [23:43] “Podríamos haber revertido el envejecimiento simplemente convirtiendo todas las células en células madre, tenemos la tecnología para hacerlo”. [31:13] "Así que estamos revirtiendo el envejecimiento del ojo, eso no es nada difícil, pero podemos revertir la edad del hígado, la piel, otros laboratorios están haciendo el bazo, el timo, a través de este método". [32:03] “La humanidad tuvo la suerte de que realmente podemos hacer esto y que hay una copia de seguridad de la juventud en cada una de nuestras células a la que se puede acceder”. [36:39] “No pensamos en cómo es al final, no es divertido. No es típicamente como, Oh, solo vete a dormir. Esos son los afortunados”. [38:55] “El concepto principal que creo que todos debemos recordar es que nuestros cuerpos responden bien a la adversidad percibida”. Sigue a David Sinclair: Sitio web: https://sinclair.hms.harvard.edu/ YouTube: https://www.youtube.com/davidsinclairpodcast Podcast: https://anchor.fm/lifespan Instagram: https://www.instagram.com/davidsinclairphd/ Twitter: https://twitter.com/davidasinclair Facebook: https://www.facebook.com/davidsinclaiphd Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, David and Peter discuss aging as a disease, the technology needed to reverse aging, and tips and tricks to increase your lifespan. You will learn about: 01:27 | Is aging a disease? 18:20 | It's never too late to begin your Longevity Mindset 25:11 | How long until we reverse aging? 47:28 | Dietary changes to increase your health David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World , and his research has been featured all over the media. Besides writing a New York Times Best Seller , David has co-founded several biotech companies, a science publication called Aging , and is an inventor of 35 patents _____________ Resources Read David’s book, Lifespan: Why We Age- and Why We Don’t Have To Levels: Real-time feedback on how diet impacts your health. levels.link/peter Consider a journey to optimize your body with LifeForce. Learn more about Abundance360 . Read the Tech Blog . Learn more about Moonshots & Mindsets. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this Ask Me Anything session, David and Peter discuss the latest age-reversal breakthroughs, getting approval from the FDA, and the possibility of living forever. You will learn about: 01:54 | Where are the breakthroughs & when are they coming? 06:46 | David Sinclair’s experience dealing with the FDA 19:16 | How are David & Peter going to reduce aging? David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World , and his research has been featured all over the media. Besides writing a New York Times Best Seller , David has co-founded several biotech companies, a science publication called Aging , and is an inventor of 35 patents _____________ Resources Read David’s book, Lifespan: Why We Age- and Why We Don’t Have To Levels: Real-time feedback on how diet impacts your health. levels.link/peter Consider a journey to optimize your body with LifeForce. Learn more about Abundance360 . Read the Tech Blog . Learn more about Moonshots & Mindsets. Learn more about your ad choices. Visit megaphone.fm/adchoices

The biologist, author and professor at Harvard Medical School, David Sinclair, has dedicated his life to research on how to prolong life. He has won numerous awards for his findings, he’s appeared in magazines like TIME, New York Times, Washington Post, and he’s also written the highly acclaimed bestseller “ Lifespan – Why we age and why we don’t have to ”. In this episode we dive deep into aging and discuss why aging doesn’t have to be something obvious in our life. We talk about how we, in the near future, might be able to stay young just by adding some molecules in our diet. But of course we also talk about how we already today may prolong our life by choosing the right diet, adding the right supplements to it and what to avoid in our lifestyle. Thank you so much for listening! ______________________________________ Biologen, författaren och professor vid Hardvard Medical School, David Sinclair, har ägnat sitt liv åt att forska hur vi kan förlänga livet. Han har vunnit en mängd priser för sin forskning och han har synts i tidningar som TIME, New York Times och Washington Post. Han är dessutom författaren bakom den hyllade bestersellern ” Lifespan – Why we age and why we don’t have to ”. I det här avsnittet så pratar vi om åldrande och varför åldrande inte behöver vara en självklarhet i våra liv. Vi pratar om hur vi kan, i en nära framtid, fortsätta att vara unga genom att bara få in rätt molekyler i vår diet. Men självklart pratar vi också om hur vi redan idag kan förlänga livet genom att välja rätt kost, addera de rätta tillskotten och vad vi bör undvika i vår livsstil. Tusen tack för att du lyssnar! Beställ " Mitt Framgångsår ". Följ Alexander Pärleros på Instagram . Följ Alexander Pärleros på Tiktok . Bästa tipsen från avsnittet i Nyhetsbrevet . I samarbete med Convendum . David Sinclair - Lifespan: Why we age and why we don't have to David Sinclair - Livslängd: Varför vi åldras och varför vi inte måste det David Sinclair podcast TallyHealth Hosted on Acast. See acast.com/privacy for more information.

The biologist, author and professor at Harvard Medical School, David Sinclair, has dedicated his life to research on how to prolong life. He has won numerous awards for his findings, he’s appeared in magazines like TIME, New York Times, Washington Post, and he’s also written the highly acclaimed bestseller “ Lifespan – Why we age and why we don’t have to ”. In this episode we dive deep into aging and discuss why aging doesn’t have to be something obvious in our life. We talk about how we, in the near future, might be able to stay young just by adding some molecules in our diet. But of course we also talk about how we already today may prolong our life by choosing the right diet, adding the right supplements to it and what to avoid in our lifestyle. Thank you so much for listening! ______________________________________ Biologen, författaren och professor vid Hardvard Medical School, David Sinclair, har ägnat sitt liv åt att forska hur vi kan förlänga livet. Han har vunnit en mängd priser för sin forskning och han har synts i tidningar som TIME, New York Times och Washington Post. Han är dessutom författaren bakom den hyllade bestersellern ” Lifespan – Why we age and why we don’t have to ”. I det här avsnittet så pratar vi om åldrande och varför åldrande inte behöver vara en självklarhet i våra liv. Vi pratar om hur vi kan, i en nära framtid, fortsätta att vara unga genom att bara få in rätt molekyler i vår diet. Men självklart pratar vi också om hur vi redan idag kan förlänga livet genom att välja rätt kost, addera de rätta tillskotten och vad vi bör undvika i vår livsstil. Tusen tack för att du lyssnar! Beställ " Mitt Framgångsår ". Följ Alexander Pärleros på Instagram . Följ Alexander Pärleros på Tiktok . Bästa tipsen från avsnittet i Nyhetsbrevet . I samarbete med Convendum . David Sinclair - Lifespan: Why we age and why we don't have to David Sinclair - Livslängd: Varför vi åldras och varför vi inte måste det David Sinclair podcast TallyHealth Hosted on Acast. See acast.com/privacy for more information.

Descarga GRATIS La Guia de 25 Creencias Empoderadoras: https://bit.ly/3eczD9S Sigue Nuestro Canal de YouTube y se parte de nuestra comunidad aqui: https://www.youtube.com/channel/UCMEJfAwHJkdpiHXuFVaFsIw El profesor de Harvard, David Sinclair, cree que no solo podemos retrasar el envejecimiento, sino que también podemos revertirlo. En este episodio de Teoría de la salud con Tom Bilyeu, David Sinclair explica los tres niveles de envejecimiento y lo que se puede hacer en cada nivel. Describe los cambios en el estilo de vida que retrasan el envejecimiento, los tratamientos farmacológicos que comienzan a detener el envejecimiento y los nuevos procedimientos experimentales que en realidad pueden revertir el envejecimiento una vez que estén completamente desarrollados. MOSTRAR NOTAS: David explica la teoría de la información del envejecimiento [0:59] David explica la diferencia entre los genes y el epigenoma [2:17] David describe la forma en que el estrés celular provoca el envejecimiento [5:20] David explica qué son las proteínas y cómo funcionan [6:40] David recomienda cambios en el estilo de vida para retrasar o revertir el envejecimiento [9:14] David recomienda estresar el sistema mediante un ayuno constante [10:52] David explica por qué no vivimos tanto como las ballenas [15:01] David describe el reinicio del reloj biológico [16:16] David explica cómo saber cuándo alguien va a morir [18:47] David explica por qué la gente está tomando metformina [20:03] David comparte su régimen de ejercicio y metformina [24:18] David aboga por la exposición al frío [25:28] David explica el trabajo que ha hecho para intentar restablecer el reloj antiguo [29:01] David explica por qué no quieres retrasar demasiado el reloj del celular [31:37] David describe el proceso real de revertir el envejecimiento en masas de células [33:20] David habla sobre algunos resultados con ratones que parecen revertir el envejecimiento [36:40] David comparte la historia de su padre sobre el uso de metformina y NMN [38:10] David explica los efectos del resveratrol [39:07] David describe los tipos de pruebas que él defiende [43:13] David comparte el impacto que quiere tener en el mundo [45:44] SIGUE A DAVID SINCLAIR: SITIO WEB: www.lifespanbook.com INSTAGRAM: https://bit.ly/2kPvLjF FACEBOOK: https://bit.ly/2mcAPiq MERCANCÍA DE LA TEORÍA DEL IMPACTO: echa un vistazo a la tienda Merch de la teoría del impacto: http://bit.ly/ImpactTheoryShop Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us as we unravel the cutting-edge discoveries and scientific breakthroughs that are reshaping our understanding of aging and healthspan. David Sinclair, a leading figure in anti-aging science, takes us on an eye-opening journey into the realm of biological age reversal, biohacking, and the secrets of extending human lifespan. Get ready to explore the revolutionary theories and interventions that could potentially unlock the fountain of youth. From the latest advancements in cellular rejuvenation to the exploration of NAD+ and sirtuins, we unpack the mind-boggling potential of reversing the aging process and staying young and healthy for longer. We also discuss the ethical implications and societal impact of increased lifespans. How might this knowledge change our approach to health, wellness, and longevity?Whether you're a science enthusiast, a health-conscious individual, or simply curious about the frontiers of human potential, this episode is a must-listen. Cited Full Episode Link: https://open.spotify.com/episode/55UlxYWPfV46f7puMkZPeD?si=eea34ffa2f044124 "David Sinclair is a Harvard researcher who believes aging is a treatable disease. His book Lifespan: Why We Age and Why We Don't have To is available now." Support this show and give love to our sponsor below: Burly Brandz Use the code fast15 - to get 15% off | www.burlybrandz.com/ Connect with Zach: Twitter | https://twitter.com/z_nix_?s=11&t=yAFtZJcxm29lxslu7pwseA Instagram | https://www.instagram.com/zachnx/ Facebook | https://www.facebook.com/zach.nx Connect with Noah: Twitter | https://twitter.com/noahreeves315?s=11&t=yAFtZJcxm29lxslu7pwseA Instagram | https://www.instagram.com/noah.reeves96/ Facebook | https://www.facebook.com/noah.reeves Subscribe to The Big Chew Podcast Twitter | https://twitter.com/thebigchewpod?s=11&t=yAFtZJcxm29lxslu7pwseA Instagram Meme Page | the_big_chew_memes https://instagram.com/the_big_chew_memes?igshid=Y2I2MzMwZWM3ZA== Instagram | the.big.chew.podcast https://instagram.com/the.big.chew.podcast?igshid=OGQ5ZDc2ODk2ZA== Popular ways to listen Apple Podcast: https://podcasts.apple.com/us/podcast/the-big-chew/id1608218162 Spotify | https://open.spotify.com/show/4hsYkpfaJdBCYa8qmTmNq3?si=8d2922dc71ba4cdc #DavidSinclair #JoeRoganExperience #LongevityResearch #AntiAgingScience #Biohacking #HealthAndWellness #ScientificBreakthroughs #FountainOfYouth #AgingReversal #Healthspan #LongevityRevolution #PodcastDiscussion #BiologicalAge #StayYoungStayHealthy #LifespanExtension

We are revisiting one of our most popular episodes to date! I’m joined by none other than Harvard scientist and world-renowned longevity expert Dr. David Sinclair. Dr. Sinclair and I discuss the most dangerous meal of the day, the benefits of “stressed out” food, and the cutting edge technology that could one day help ALL of us live healthy lives into our 100s — and beyond. We even discuss the one food secret that all of the world’s longest-living populations share. Full show notes and transcript: https://drgundry.com/david-sinclair-2 Thank you to our sponsors. Check them out: Visit www.DryFarmWines.com/GUNDRY for an extra bottle of wine with your first order for just one cent! Find your perfect sofa today at 20% OFF at www.Allform.com/GUNDRY Use promo code GUNDRY to save $1,000 on a Michael Phelps Swim Spa or $500 on a Master Spas Hot Tub at www.MasterSpas.com. Go to www.Truebill.com/GUNDRY - it could save you $$$ a year. Pendulum is offering a 20% discount on your first month of an Akkermansia membership with code GUNDRY20, www.pendulumlife.com For savings on your prescriptions, go to www.Good RX.com/gundry. Get a quote today at www.Progressive.com and see why 4 out of 5 new auto customers recommend Progressive. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today’s guest is Dr. David Sinclair, who is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. After obtaining his PHD and working as a postdoctoral researcher at M-I-T, he was recruited to Harvard Medical School where he has been teaching aging-biology and translational medicine for aging for the past 16 years. He’s launched his own podcast, Lifespan , which I’m so proud of him for. Make sure to check that out after the interview. In this episode we discuss: The science behind reversing your age. The daily habits David recommends to easily improve your lifespan. The biggest things that are shortening your lifespan. Why you should trick your body into thinking it’s dying. How future technology and the metaverse will affect aging. And so much more! For more go to: www.lewishowes.com/1232 Check out Dr. David Sinclair's new podcast: Lifespan Dr. David Sinclair's previous episodes: www.lewishowes.com/904 www.lewishowes.com/1004 See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .

Most of us want to live as long as possible. It’s a SURVIVAL INSTINCT that’s hard-wired into our DNA. BUT IT’S NOT ENOUGH TO LIVE A LONG LIFE. OUR QUALITY OF LIFE MATTERS, TOO. Unlocking the secrets to a long, healthy life has CHALLENGED MANKIND since the dawn of medical science. Those of you who know me, also know I’ve been fascinated by this subject for quite a while, too. That’s why it’s a great privilege to welcome back this week’s guest, DR. DAVID SINCLAIR. He is a LEADING SCHOLAR and Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at HARVARD MEDICAL SCHOOL where he has been teaching aging biology and translational medicine for aging for the past 16 years. More than that, he is also a foremost researcher best known for his work on UNDERSTANDING WHY WE AGE and HOW TO SLOW ITS EFFECTS. Contemporary BLEEDING EDGE RESEARCH and scientific advancements have propelled us forward and not only UNLOCKED SECRETS TO LONGEVITY but have also created new questions and curiosities that continue to excite our BEST AND BRIGHTEST MINDS. And few people on planet earth are as well versed or as educated on this subject as Dr. Sinclair. He lives in a world filled with deep examinations of hormesis, sirtuins, energy metabolism, biosynthesis, mTOR levels, reprogramming genes, mitochondria, learning and memory, time-restricted feeding and caloric restrictions, neurodegeneration, and cancer. While many of you may AWESTRUCK by this area of science, you should also be EXCITED by Dr. Sinclair’s research, because one day it will have a DIRECT IMPACT on you. This week, we’re going to translate what that research means to you in practical terms…and it’s coming sooner than you think! Dr. Sinclair covers a wide range of topics from red light therapy, to the effects of glucose on our bodies, hormone replacement, and the importance of being physically active, fasting, and not eating meat. We also touch on ALTERING DNA which holds the possibility of significantly extending life, and CURING HORRIFIC DISEASES like cancer, MS, Alzheimer’s, Parkinsons, and many others. Our discussion isn’t just about theories and research though. Dr. Sinclair has also got some HANDS-ON TIPS on what you can do to start to start feeling and looking younger right now. So, sit back, relax, and LEARN. CLASS IS ABOUT TO BEGIN, and I guarantee, you won’t want to miss it. Learn more about your ad choices. Visit megaphone.fm/adchoices

David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics. Time Stamps: 0:35:27 Podcast begins with David Sinclair 0:36:25 Is when we eat more important than what we eat? 0:38:45 What is the connection between time restrictive eating and longevity? 0:43:54 What causes us to age? 0:45:46 Epigenetic change. 0:52:03 What causes DNA breaks? 0:55:28 What plant foods create DNA breaks? 0:57:13 PARP enzymes 1:00:46 Where does NAD come from? How do we make it? What enzymes use it? 1:04:50 NAD recycling pathway. 1:12:13 Sirtuins. 1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins? 1:31:50 Does being in a ketogenic state increase NAD? 1:40:30 Xenohormesis and plant molecules. 1:45:50 Resveratrol trials. 1:51:55 mTOR. 1:57:25 David’s thoughts on animal protein. 2:04:03 Meat consumption in relation to the environment and regenerative agriculture. 2:11:28 Where to find David Sinclair. David’s info: https://genetics.med.harvard.edu/sinc.. . https://lifespanbook.com/ Instagram: @davidsinclairphd Twitter: @davidasinclair Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order The Cold Plunge: TheColdPlunge.com, use code CarnivoreMD for $111 off your cold plunge Eight Sleep: https://www.eightsleep.com/carnivoremd use code “CARNIVOREMD” to save $150 Sacred Hunting: www.sacredhunting.com/Paul for $250 off your hunt

I am honored to share the first episode of the new podcast, Lifespan with Dr. David Sinclair . Dr. Sinclair is a professor of genetics at Harvard Medical School. He is also the co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. David is both a friend and a colleague, and I am delighted to have helped him in the creation of this new podcast. It will be an 8-episode series that provides a deep dive into the science behind why we age and the newest research on what we can do to slow, stop and even reverse aging. While we have Episode 1 of the Lifespan podcast here, please be sure to navigate over to the Lifespan with Dr. David Sinclair podcast channel to subscribe. New episodes will come out every Wednesday for the next 8 weeks. I am certain that you will both enjoy it and learn from it. Show notes for this episode can be found on the Lifespan with Dr. David Sinclair podcast channel . Title Card Photo Credit: Mike Blabac Disclaimer

David Sinclair, Ph.D.: “I’ve been getting younger for the past decade, and the biggest impact has been the change in my eating habits.” Sinclair, a longevity expert and Harvard geneticist, joins mbg co-CEO, Jason Wachob, to discuss our 2022 Wellness Trend of making longevity easier and more accessible, plus: - Why avocados are a top longevity food (~27:59) - The power of rest for living longer (~14:35) - How the science of longevity has updated in the past year (~02:36) - How to make sure your body absorbs resveratrol (~07:39) - How to practice hot-cold therapy at home (~15:52) Referenced in the episode: - Read our 2022 Wellness Trend on the pursuit of longevity for all . - Read all of our 2022 Wellness Trends . - mbg Podcast episode #217 & #170 , with Sinclair. - Sinclair's book, Lifespan . - The Sinclair Lab . - A study showing alpha-ketoglutarate-based supplement reversed biological age by an average of eight years . - mbg Podcast episode #275 , with Serena Poon. - mbg Podcast episode #47 , with Valter Longer, Ph.D. Enjoy this episode sponsored by sonos ! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com . Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022. In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it. Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Dr. David Sinclair, Harvard Medical School 00:03:45 Sponsors: AG1, LMNT & Waking Up 00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging 00:10:23 What Causes Aging? The Epigenome 00:15:53 Cosmetic Aging 00:17:15 Development Never Stops, Horvath Clock 00:20:12 Puberty Rate as a Determinant of Aging Rate 00:23:00 Fasting, Hunger & Food Choices 00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy 00:34:50 Caffeine, Electrolytes 00:35:56 Blood Glucose & the Sirtuins; mTOR 00:37:55 Amino Acids: Leucine, “Pulsing” 00:44:35 Metformin, Berberine 00:50:29 Resveratrol, Wine 00:53:20 What Breaks a Fast? 00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing 01:09:10 Are Artificial Sweeteners Bad for Us? 01:12:04 Iron Load & Aging 01:15:05 Blood Work Analysis 01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary 01:26:02 Amino Acids, Plants, Antioxidants 01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen 01:40:35 Neuroplasticity & Neural Repair 01:46:19 Ice Baths, Cold Showers, “Metabolic Winter” 01:48:07 Obesity & How It Accelerates Aging, GnRH 01:52:10 Methylation, Methylene Blue, Cigarettes 01:56:17 X-Rays 01:59:00 Public Science Education, Personal Health 02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com 02:08:13 Zero-Cost Support & Resources, Sponsors, Supplements, Instagram Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices 🧬 DOWNLOAD THE PDF SUMMARY: Don't miss the specific dosages and timing protocols discussed today. Get the full visual guide and supplement breakdown here: 👇 https://goo.su/VOTEb Verified Science Resources.