David Sinclair

David Sinclair was a long-running rock critic for the Times, Rolling Stone and many others and now makes records himself. He looks back here at some of the first bands he saw and the extraordinary people he interviewed, which touches on … … the day Bowie took him to the Hammersmith Odeon to stand on the spot where he announced his retirement … Keith Richards’ dark side (and what he said about Lady Di) … interviewing Prince “who seemed like a shadow” … seeing Free in 1970: “I still think about it. Some bands are like footprints in fresh snow” … Hendrix on a bill with Cat Stevens and the Walker Brothers when he was 14 … singles he wore out in the days when you had to change the needle … his theory about the lyrics of Crossroads … “the Simon Templar of rock journalism” … the purgatory of being a serious musician when Spotify adds 100,000 new tracks a day … and the Shadows, the Scorpions, Sting, ZZ Top, David Coverdale and … Millstone Grit. David Sinclair’s music here: https://open.spotify.com/artist/4oMczlXHj1pt6M4ZNGR14E?si=_9Dx_G_UQ3GifCFGFra07A To buy here: https://www.davidsinclairfour.com/shop Tickets to the 100 Club, May19: https://www.solidentertainments.com/100club/index.html Help us to keep the conversation going: https://www.patreon.com/wordinyourear Help us to keep The Longest Continuous Conversation In Rock'n'Roll going: https://www.patreon.com/wordinyourear Hosted on Acast. See acast.com/privacy for more information.

Dr. Rich Handley explores Dr. David Sinclair’s latest breakthroughs in gene therapy, epigenetic resets, and the future of reversing biological aging. ---- In this episode, I break down Dr. David Sinclair’s groundbreaking work on reversing aging through gene therapy and cellular reprogramming. We explore what it means to turn back the biological clock, what “longevity escape velocity” could look like, and how we might one day reset our bodies to a younger state. I also share my reflections on what such a future means for health, purpose, and the human experience. ---- Dr. David Sinclair is a Harvard Medical School professor and one of the world’s leading researchers on aging and longevity. His pioneering work on sirtuins, epigenetic reprogramming, and Yamanaka factors has reshaped how we understand biological aging. As co-founder of Life Biosciences and author of Lifespan: Why We Age—and Why We Don’t Have To , Dr. Sinclair continues to advance the science of reversing age-related decline through cutting-edge genetics and biotechnology. ---- Dr. David Sinclair YouTube: https://www.youtube.com/@Richard.Handley LinkedIn: https://www.linkedin.com/in/drhandley/ ---- PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠ ---- Disclaimer *Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Send us Fan Mail Trail running enthusiasts and adventure seekers, you're in for a treat! Join us as we chat with the phenomenal David Sinclair, a mountain running and ski mountaineering powerhouse who has been making waves with his record-breaking performances. Discover the secrets behind his awe-inspiring run at the JFK 50 and his ambitions for the ski mountaineering season as the 2026 Olympic cycle approaches. David opens up about the strategic choices that have shaped his career, including his move back to Vermont to fully commit to his athletic pursuits. Explore the dual sporting world of David Sinclair as he shares his journey from competitive cross-country skiing to dominating the ultra-running and ski mountaineering scenes. Hear firsthand how he transitioned from a coaching role in California to focus entirely on his athletic career, leading to impressive achievements at events like the Broken Arrow Skyrace and Speedgoat. David's unique training methods, which involve balancing high-altitude skiing with reduced running mileage, offer fascinating insights into the crossover success of skiers in the world of ultra-running. What drives a champion? David Sinclair's competitive mindset offers a glimpse into what it takes to excel at both ultra distances and ski racing. Learn about his thoughts on competing against some of the world's top athletes and his aspirations for Olympic participation in ski mountaineering. As you listen to this episode, you'll be inspired by David's dedication to pushing the boundaries of mountain sports, and you'll gain valuable takeaways on balancing performance with the joy of adventure. Don't miss this chance to get inside the mind of a true mountain legend! David Sinclair - https://www.instagram.com/david.a.sinclair.92/?hl=en Use code SteepStuff for 20% your cart on Sidas.us Follow James on IG - @jameslauriello Follow the Steep Stuff Podcast on IG - @steepstuff_pod Follow Sidas USA on IG - @sidas_usa

David Sinclair may have a case for Trail Runner of the Year after the most impressive race of the year. He broke the course record at JFK 50 miler. This is a race that Jim Walmsley, Adam Peterman, and Zach Miller have run, and he broke Hayden Hawks record by 10 minutes! We discuss his race strategy, the importance of nutrition, and the unique challenges of transitioning between trail and road shoes. Sinclair reflects on his journey to recognition and sponsorship in the ultra-running community, balancing his passions for skiing and trail running. He emphasizes the significance of strength training and shares insights into his training regimen. The conversation also touches on the distinct challenges of East Coast trails compared to their West Coast counterparts, the role of heat training in performance, and his aspirations for the future. Sound Bites "Winning the JFK 50 was surreal for me." "Grit and resilience define my journey." takeaways David Sinclair set a course record at the JFK 50 miler. He emphasizes the importance of head-to-head competition over time goals. Transitioning between trail and road shoes is a unique challenge. Nutrition planning is crucial for long races. Winning the JFK 50 was a surreal experience for Sinclair. Recognition and sponsorship in ultra running can be slow to come. Balancing skiing and trail running is a key focus for Sinclair. Strength training plays a significant role in his training regimen. Sinclair aims for Olympic aspirations in ski mountaineering. East Coast trails present unique challenges compared to West Coast trails. Chapters 00:00 David Sinclair's JFK 50 Victory and Course Record 07:55 Transitioning Between Trail and Road Shoes 13:45 The Thrill of Winning and Breaking Records 19:28 Navigating Sponsorship and Career Decisions 24:57 The Road to the Olympics and Team Dynamics 33:53 Overcoming Challenges in Competition 40:42 Training Structure and Recovery 45:42 Threshold Workouts and Race Preparation 51:28 Heat Training and Its Benefits 57:25 Weekly Mileage and Training Volume keywords: David Sinclair, JFK 50, ultra running, race strategy, nutrition, sponsorship, trail running, skiing, training regimen, strength training

In this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking research on the role of epigenetic changes in aging and the potential to reverse this process. He explains how lifestyle factors, such as diet and exercise, can greatly impact our longevity, and highlights the importance of regularly monitoring health markers like blood glucose and cholesterol. Dr. Sinclair emphasizes the power of technology, including blood tests and personalized health tracking, to help individuals live healthier, longer lives. The conversation also dives into cutting-edge research on longevity drugs and therapies, including gene therapy and reprogramming cells to a younger state. Dr. Sinclair discusses the promising future of treatments aimed at reversing aging and improving the quality of life well into old age. Episode highlights: Introduction: 00:00:00 Why have you decided to be a scientist and not a painter: 00:02:40 What is the difference between healthspan and lifespan: 00:06:00 Can we extend our lifespan: 00:07:10 What should you do to increase your healthspan: 00:09:40 How can we increase our lifespan: 00:14:45 Upcoming Season of David’s Podcast: 00:19:40 GLP-1 as a longevity drug: 00:21:40 The information theory of aging: 00:25:40 How are cells and organisms reprogrammed in the lab: 00:30:10 What are the future opportunities in cell reprogramming: 00:32:50 What is the effect of reprogramming on cancer cells: 00:36:00 What is the effect of reprogramming on senescent cells: 00:38:50 David's top tip for healthspan: 00:42:10 Epigenetic Changes Drive the Aging Process David Sinclair explains that aging is not just wear and tear on the body, but a loss of information within cells. This concept, known as epigenetic aging, involves cells losing their ability to read the right genes at the right time. As cells age, they lose their identity, leading to aging and age-related diseases. The exciting part of this discovery is that these changes may be reversible. Dr. Sinclair’s research focuses on reprogramming cells to restore their youthful function, potentially turning back the biological clock and extending healthspan and lifespan. Lifestyle Choices Are Key to Longevity David Sinclair emphasizes that simple lifestyle choices—like diet, exercise, and regular health monitoring—can have a profound impact on both healthspan and lifespan. He stresses the importance of moving regularly, avoiding processed foods, and maintaining a healthy weight. These actions, along with monitoring key biomarkers such as glucose and cholesterol, are crucial in delaying the onset of age-related diseases. Sinclair’s father, who at 85 is in excellent health, serves as a prime example of how these practices can help people live healthier, longer lives. We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast

A Note from James:I particularly want to reverse my aging. I'm not concerned about being able to run a mile or anything like that; I just want to reverse the aging of my brain. I feel there's a definite difference between my brain now and when I was younger. By the way, culturally, we acknowledge that the brain ages. Not only medically, but culturally, you have to adapt to being the wise older person rather than the sharp young person.We had a great conversation with Arthur Brooks about this. He wrote an excellent book, which I can't recommend enough, called "From Strength to Strength." That podcast with Arthur Brooks changed my life in how I view my brain aging. Additionally, several podcasts with David Sinclair about the aging process have also been life-changing.I have used the supplements he recommended and made the lifestyle changes he suggested back in 2019. David has conducted a lot of research in the five years since his book "Lifespan" was released, and I wanted to see what the current state of his research was. So, he came on the podcast.I'm very grateful; he doesn't do many podcasts. He shared some incredible discoveries and new information, giving me real insight. We discussed everything related to what he's doing in anti-aging and what he's discovered since the last time I had him on. At the special request of our listeners, I also asked him about testosterone.Towards the end of the podcast, I asked him about that, and his answer was very interesting. Here's David.Episode Description:Today, James discusses personal motivations for wanting to reverse aging, specifically targeting brain aging. The conversation moves into the broader cultural and scientific understandings of aging, touching on insights from Arthur Brooks and David Sinclair's research. Sinclair's work on anti-aging, including lifestyle changes and supplement use recommended by him, is highlighted, mentioning his book 'Lifespan' and the progress in his research over the past five years. Key discussions include the information theory of aging, the role of DNA and epigenetics in aging, and the concept of age reversal through maintaining or restoring the epigenome's integrity. The episode covers the potential of using Yamanaka factors for age reversal, the challenges in translating these findings from mice to humans, and regulatory considerations for human trials. Sinclair also touches on his ongoing work in developing chemical cocktails for age reversal, comparing lifestyle changes to these scientific advances. Episode Summary:00:00 The Quest for Age Reversal: Personal Motivations and Influential Conversations01:11 Diving Deep into David Sinclair's Research on Anti-Aging02:24 Exploring the Information Theory of Aging and DNA's Role04:30 The Potential of Epigenetics in Reversing Aging07:14 The Challenges and Ethics of Age Reversal Technologies09:01 The Future of Anti-Aging: From Gene Therapy to Accessible Pills10:53 Debunking Myths and Addressing Controversies in Anti-Aging Supplements15:13 The Cutting-Edge of Aging Research: Yamanaka Factors and Epigenetic Reset25:05 The Philosophical and Practical Implications of Rejuvenation Research27:57 Unveiling New Breakthroughs in Cellular Biology28:19 Decoding the Mystery of Emanarcha Factors29:18 Exploring the Potential of Yamanaka Factors in Age Reversal29:43 The Future of Age Reversal: From Theory to Practice30:52 Innovative Approaches to Rejuvenation and Safety Measures31:52 Understanding the Complexity of Aging Across Different Organs34:57 The Fascinating World of Epigenetic Aging and Brain Plasticity37:20 Pushing the Boundaries: Chemical Cocktails for Rejuvenation39:46 Comparing Lifestyle Factors and Chemical Interventions in Aging40:56 Exploring the Possibilities of Reversing Menopause in Mice45:09 Navigating the Path to Human Trials and Regulatory Approval49:18 The Potential and Ethics of Off-Label Uses for...

The book information. Buy on Amazon: https://www.amazon.com/dp/B07N4C6LGR?tag=9natree-20 These are takeaways from this book. Firstly, The Information Theory of Aging, One of the core topics Sinclair discusses is the 'Information Theory of Aging.' According to this theory, aging results from the loss of information within our cells, particularly in the epigenome. The epigenome, which controls how our genes are expressed without altering the DNA itself, can be thought of as the software that operates our genetic hardware. Sinclair argues that as we age, environmental factors, lifestyle choices, and even the process of cell division can lead to 'epigenetic noise,' which disrupts the functioning of our genes. Over time, this contributes to the decline associated with aging. Sinclair suggests that if we can develop methods to reset this epigenetic information back to a youthful state, we could theoretically halt or reverse the aging process. Secondly, Sirtuins and Their Role in Longevity, A significant part of the book is devoted to sirtuins, a family of proteins that Sinclair and other researchers have found to play a key role in longevity. Sirtuins regulate a variety of cellular processes, including DNA repair, inflammation reduction, and the maintenance of cellular health. They are activated by certain lifestyle factors and compounds, such as exercise, calorie restriction, and the compound resveratrol—a component of red wine. Sinclair's research suggests that activating sirtuins can delay aging and improve health, pointing towards potential interventions for extending human lifespan. Thirdly, NAD+ and Its Importance in Aging, Another central topic in 'Lifespan' is the role of nicotinamide adenine dinucleotide (NAD+), a coenzyme present in all living cells and crucial for cellular metabolism. Sinclair discusses how NAD+ levels decline with age, significantly affecting the body's ability to repair DNA and maintain cellular health. This decline contributes to aging and an increased risk of age-related diseases. Sinclair highlights research on how boosting NAD+ levels—through diet, lifestyle, and supplements—can enhance sirtuin activity, improve cellular function, and potentially extend lifespan. Fourthly, The Potential of Gene Therapy, Sinclair also explores the exciting possibilities of gene therapy in combating aging. He discusses cutting-edge research, including his own, into using gene therapy to deliver specific genes directly into the body. These genes could potentially repair damaged DNA, increase NAD+ levels, activate sirtuins, and revert aged cells back to a younger state. While still in the early stages, this research could pave the way for treatments that significantly extend human life while reducing the burden of age-related diseases. In conclusion, ‘Lifespan: Why We Age—and Why We Don’t Have To’ is a must-read for anyone interested in the science of aging and longevity. David Sinclair provides a compelling case for viewing aging as a treatable condition, supported by decades of research and potential scientific breakthroughs. The book is not just a catalogue of future technologies; it also provides practical advice on how to extend life and improve health through accessible lifestyle changes today. This work is particularly relevant for scientists, healthcare professionals, and anyone looking to understand the mechanisms of aging and how we might extend our healthspan. Sinclair’s vision is a world where we can live long, healthy lives, free from the constraints of age-related disease. His book is an invitation to envision and work toward this future, making it a transformative read for anyone dedicated to improving their lifespan and healthspan. References: https://mybook.top/read/B07N4C6LGR/

0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Welcome to the "One Meal A Day with David Sinclair" podcast, where we explore groundbreaking research and discoveries in the field of aging and health. Join us as we dive into fascinating conversations with renowned scientist David Sinclair, known for his pioneering work in the molecular biology of aging. In each episode, David Sinclair delves into cutting-edge topics and shares his insights on how we can live healthier, longer lives. From exploring the latest breakthroughs in anti-aging science to discussing practical lifestyle strategies, this podcast is your go-to resource for unlocking the secrets of longevity. With his warm and engaging style, David Sinclair invites experts from various disciplines to join him in thought-provoking discussions. Together, they explore the potential of emerging technologies, delve into the science behind nutrition and exercise, and examine the impact of genetics and epigenetics on the aging process. Whether you're a lifelong health enthusiast, a curious individual seeking to understand the science of aging, or someone looking for practical tips to optimize your well-being, this podcast offers valuable insights and actionable advice. Join us on this enlightening journey as we unravel the mysteries of aging and discover how we can age well with grace and vitality. Get ready to challenge conventional wisdom, embrace innovative ideas, and take control of your health. Tune in to the "One Meal A Day with David Sinclair" podcast and embark on a transformative exploration of the science of longevity. Note: This podcast is for informational purposes only and should not be considered as medical advice. Please consult with a healthcare professional before making any changes to your lifestyle or implementing any recommendations discussed in the episodes.

Renue by Science 10% Discount Code: MYNMN ( https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN ) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB Youth & Earth 15% Discount Code: MYNMN ( https://youthandearth.com?sca_ref=3766764.knrWl4O3cB ) ProHealth 15% Discount Code: MYNMN ( https://www.prohealth.com/ ) DoNotAge 10% Discount Code: MYNMN ( https://bit.ly/2VBDgNt ) So, following my Renue by Science Subscription Service Video, I received this comment form AK asking if I could do an updated David Sinclair Longevity Stack video using the new 15% off prices, AK asked, so here it is… So, in this video I will only look at the supplements in David Sinclair’s Stack that can be bought from Renue by Science, so I won’t include aspirin or yogurt as I normally do. · As before, I will only cover what he says David Sinclair actually states in his book, or has specifically mentioned on his podcast or when being interviewed on YouTube one-on-one There are a number of other Health type Blogs etc. that say or assume he takes other things, but I shall not include those. As we know NMN is used to raise our NAD levels: · 100 grams of NMN powder from Renue by Science will cost you $114.95 · Add to that the 15% MYNMNSUB discount and that drops to $97.71 · That in turn works out at $0.97 a gram · Cost per month = $29.10 · Cost per year = $349.20 Resveratrol And according to David Sinclair it is accelerator pedal for NMN, it promotes hormesis, and it also activates the sirtuins He mixes resveratrol powder into his yogurt at breakfast, you can buy it in capsules, but then you would need to break them open to mix with a fatty food, so I have only looked at powder options · 100 grams of resveratrol powder from Renue by Science will cost you $84.95 · Add to that the 15% MYNMNSUB discount and that drops to $72.21 · That in turn works out at $0.72 a gram · Cost per month = $21.60 · Cost per year = $259.20 Metformin As you know David Sinclair uses Metformin, he has mentioned 800mg & 1g as his dose, taken at night, but in many countries, Metformin is a prescription drug, those that can’t get it tend to use Berberine instead, so that is what I have costed · 90 x 150mg capsules of Liposomal Berberine from Renue by Science will cost you $49.95 · Add to that the 15% MYNMNSUB discount and that drops to $42.46 · That in turn works out at $0.47 per capsule · Cost per month = $14.10 · Cost per year = $169.20 Vitamins D3/K2 David Sinclair says he takes Vitamin D. Vitamin D regulates calcium and maintenance of phosphorus levels in the blood. These factors are vital for maintaining healthy bones. Vitamin D also allows the intestines to stimulate and absorb calcium, and reclaim the calcium that the kidneys would otherwise · 60 x 2 milliliter doses (that’s 2,500 IU) of Vitamin D3 from Renue by Science will cost you $22.95, it also includes 250 micrograms of Vitamin K2 · Add to that the 15% MYNMNSUB discount and that drops to $19.51 · That in turn works out at $0.32 per day · Cost per month = $9.60 · Cost per year = $115.20 But why include Vitamin K2? K2 ensures that the calcium goes to our bones and teeth and not our soft tissue like our kidneys. TMG · After much debate and rumor mongering in an interview with Dr. Mercola David Sincl

If you follow David Sinclair, you know he takes 1 gram of resveratrol every day. This is a contradiction to what he discovered in his studies, and what the rest of longevity studies on resveratrol show. When I discovered that in Sinclair's study, low resveratrol had the best longevity results, the first thing I did - was trying to get Dr. David Sinclair’s response. Did he answer me? You’re about to find out. In the last part of this resveratrol series, we will try to answer: - Why does Dr. David Sinclair take 1 gram even though in his studies lower dose worker better for longevity? I’ve gone on many David Sinclair Interviews, and collected for you five segments where Dr. Sinclair touches this critical issue: thy he takes so much resveratrol? And we’ll also conclude this 5-episode resveratrol investigation ✅ Check the new longevity course:https://wellnessmessiah.com/course

Descarga GRATIS La Guia de 25 Creencias Empoderadoras: https://bit.ly/3M4s2qC ¿Estamos más cerca de volvernos biológicamente inmortales? ¿Qué te esforzarías por hacer o qué soñarías si pudieras extender tu vida a 150 años? Hasta hace poco, la idea de la longevidad se sentía más como llegar a los 90 y posiblemente a los 100 en el mejor de los casos, y si logra lograr ese objetivo, lo mejor y lo esperado sería una alta calidad de vida. Pero, ¿y si pudieras extender tu vida útil incluso 10 años? Asegurarse de que esos años sean emocionantes y significativos sería una prioridad. El Dr. David Sinclair, un genetista de renombre mundial, se une a Tom en este episodio para desglosar exactamente por qué envejecemos a nivel celular y qué se está volviendo posible ahora en términos de ralentizar nuestro reloj biológico e incluso posiblemente revertirlo, nuestra edad biológica. Si desea saber qué puede hacer para comenzar a mejorar la calidad de vida de su envejecimiento y mantenerse joven por más tiempo, este episodio es para usted, y querrá consultar el podcast más reciente del Dr. David Sinclair, Lifespan (enlace a continuación). CAPITULOS 0:00 | Introducción a David Sinclair 0:28 | Por qué envejecemos 9:40 | Lo que va mal con el envejecimiento 23:44 | Cómo revertir el envejecimiento 37:35 | Enfrentar la adversidad 45:37 | Cómo funciona la metformina 55:02 | Estilo de vida para la longevidad CITAS [23:43] “Podríamos haber revertido el envejecimiento simplemente convirtiendo todas las células en células madre, tenemos la tecnología para hacerlo”. [31:13] "Así que estamos revirtiendo el envejecimiento del ojo, eso no es nada difícil, pero podemos revertir la edad del hígado, la piel, otros laboratorios están haciendo el bazo, el timo, a través de este método". [32:03] “La humanidad tuvo la suerte de que realmente podemos hacer esto y que hay una copia de seguridad de la juventud en cada una de nuestras células a la que se puede acceder”. [36:39] “No pensamos en cómo es al final, no es divertido. No es típicamente como, Oh, solo vete a dormir. Esos son los afortunados”. [38:55] “El concepto principal que creo que todos debemos recordar es que nuestros cuerpos responden bien a la adversidad percibida”. Sigue a David Sinclair: Sitio web: https://sinclair.hms.harvard.edu/ YouTube: https://www.youtube.com/davidsinclairpodcast Podcast: https://anchor.fm/lifespan Instagram: https://www.instagram.com/davidsinclairphd/ Twitter: https://twitter.com/davidasinclair Facebook: https://www.facebook.com/davidsinclaiphd Learn more about your ad choices. Visit megaphone.fm/adchoices