Martin Shkreli

Sign up for TBPN’s daily newsletter at TBPN.com (01:22) - SpaceX's Lunar Mass Driver (41:12) - 𝕏 Timeline Reactions (54:37) - AI Coming for Zuck's Job (58:17) - The Great Peptide Debate w/ Martin Shkreli & Max Marchione. Martin Shkreli, often referred to as the "Pharma Bro," is an American investor and former pharmaceutical executive known for his controversial decision to drastically increase the price of the life-saving drug Daraprim. In the conversation, Shkreli expresses skepticism about the growing popularity of peptides, attributing it to psychological factors like identity control and distrust of institutions. He emphasizes the importance of adhering to established pharmaceutical practices and regulatory frameworks to ensure drug safety and efficacy. Max Marchione is the co-founder of Superpower, a health optimization platform focused on proactive, data-driven care and longevity. He works at the intersection of consumer health, diagnostics, and software, building tools that give users deeper visibility into their biology and long-term health. (01:31:35) - Mitchell Green, founder and managing partner of Lead Edge Capital, discusses the firm's recent closure of its $3.5 billion Fund 7, highlighting the strong interest from both existing and new limited partners. He emphasizes Lead Edge's unique approach, leveraging a diverse LP base of world-class executives and entrepreneurs to support portfolio companies through customer introductions, recruiting, and advisory roles. Green also addresses the resilience of the software industry, countering notions of a "SaaS apocalypse" by underscoring the enduring value and stickiness of enterprise software solutions. (01:43:28) - Shane Hegde, co-founder and CEO of Air, a creative operations platform, discusses the company's recent initiatives, including a new ad campaign in The New York Times and their most significant product release to date. He emphasizes that while AI is a powerful tool, it cannot replace the deeply subjective and perfection-driven nature of creative work. Hegde introduces five new features launching tomorrow: access to 50 AI models within Air, a canvas editor for asset manipulation, AI agents for automated edits, a context layer to maintain brand consistency, and a shift to usage-based pricing. (01:52:53) - Dr. Adam Oskowitz, co-founder and Chief Medical Officer of Doctronic, discusses their AI-native care platform that offers free, 24/7 health consultations, connecting users to licensed doctors across all 50 states for $39 per visit. He highlights the platform's efficiency, enabling doctors to see more patients per hour compared to traditional telehealth services, and mentions a pilot program in Utah where their AI system can renew prescriptions without direct physician involvement. Additionally, Dr. Oskowitz notes that the platform's ease of use encourages users to seek care they might otherwise forgo, addressing the longstanding supply-demand mismatch in medicine. (02:00:16) - Robin Vince, CEO of BNY Mellon, discusses the bank's strategic focus on integrating artificial intelligence (AI) to enhance operational efficiency, enrich client services, and expand its service offerings. He highlights the development of Eliza, BNY Mellon's enterprise AI platform, which supports over 125 AI-enabled solutions and empowers employees to build custom AI agents, fostering a culture of innovation. Vince also emphasizes the importance of responsible AI adoption, underscored by BNY Mellon's collaboration with Carnegie Mellon University to advance AI research and education. (02:17:26) - David Senra is the host of the Founders podcast, where he studies and distills the lives of history’s greatest entrepreneurs. Through deep dives into biographies of figures like Steve Jobs, Estée Lauder, and Henry Ford, he focuses on the patterns, habits, and principles behind building e

James Altucher Show: Read the notes at at podcastnotes.org . Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- A Note from James: Is he the most hated man in America? I don’t think so. Martin Shkreli was notorious for various reasons that you’ll hear about in this episode—there are some crazy stories—but I’ve come to know Martin over the past few months as both a friend and business partner. Let’s just hear his stories and explanations. I think you’ll agree with me that this is one of the smartest people I’ve ever had on the podcast. Episode Description: Martin Shkreli became one of the most controversial figures in business history—labeled “the most hated man in America,” prosecuted, imprisoned, and publicly vilified. In this conversation, he tells his side of the story. Part 1 focuses on how media narratives form, why conviction and risk-taking matter in entrepreneurship, and the deeper mechanics behind the pharmaceutical controversy that made him famous. He explains the economics of drug pricing, insurance systems, neglected medications, and why public perception diverged so dramatically from what patients actually experienced. The episode also explores learning across disciplines, intellectual courage, prosecutors’ incentives, and how public scandals evolve into legal consequences. Whether you agree with him or not, the discussion raises uncomfortable questions about business, regulation, media, and reputation. What You’ll Learn: Why media narratives can shape public opinion more than facts The real economics behind pharmaceutical pricing and insurance coverage How entrepreneurs learn complex industries without formal training Why conviction and risk tolerance are essential in investing and business How incentives within legal and political systems influence outcomes Timestamped Chapters: [00:02:00] “Most Hated Man in America” — Media Narratives & Reputation [00:03:11] A Note from James [00:03:45] Humor vs. Backlash: Handling Public Criticism [00:06:39] Conviction, Investing & Standing Your Ground [00:09:00] Optimism, Forgiveness & Business Relationships [00:12:08] The Pharma Controversy Begins [00:14:52] From Hedge Funds to Biotech CEO [00:17:40] Learning New Industries from Scratch [00:19:00] Staying Curious & Avoiding Fear of Complexity [00:21:00] Borrowing Knowledge Across Domains [00:23:06] How People Actually Learn Complex Skills [00:29:00] Entrepreneurship, Ego & Motivation [00:31:20] The Daraprim Pricing Decision Explained [00:34:00] Neglected Drugs & Pharma Economics [00:37:00] Profit Motive vs. Public Good [00:41:13] Why He Became the Target [00:45:00] Prosecutors, Incentives & Legal Strategy [00:47:00] Hedge Funds, Technical Violations & Trials [00:50:00] High-Profile Cases & Selective Enforcement [00:53:00] Media Attention & Personal Decisions See Privacy Policy at https://art19.com/privacy and California Privacy Notice at <a href="https://art19.com/privacy#do-not-sell-m

A Note from James: In the last episode, we talked about whether Martin Shkreli really deserves the label “most hated man in America.” My conclusion was no, and I hope you came to the same conclusion after hearing his perspective. In this episode, we shift gears completely. We talk about Bitcoin, crypto, AI, energy, optical computing, and what the future of technology might actually look like. Martin has a very unusual combination of skills—finance, biotech, programming—and I always enjoy hearing how he connects ideas across different fields. That’s what this conversation is about. Episode Description: What happens when AI demand collides with the limits of computing power and energy? In Part 2, Martin Shkreli and James explore the future of technology—from crypto vulnerabilities to optical computing, GPU scaling, and the potential energy crisis driven by artificial intelligence. They discuss whether Bitcoin can survive quantum computing, why stablecoins solve real-world financial problems, and how computing architecture may shift beyond traditional silicon chips. The conversation then moves into AI economics: why companies might spend billions on compute to make better decisions, how energy constraints could shape innovation, and why optical computing could become the next major breakthrough. This episode isn’t about controversy—it’s about technological leverage, incentives, and where computation is heading next. What You’ll Learn: Why quantum computing could eventually threaten Bitcoin’s encryption The real-world advantages of stablecoins and decentralized payments How AI demand could create massive new energy constraints Why optical (photonic) computing may outperform traditional silicon chips How businesses might use large-scale AI compute for strategic decisions Timestamped Chapters: [00:02:00] Bitcoin, Encryption & Quantum Computing Risks [00:03:02] A Note from James [00:03:34] Crypto Markets: Speculation vs. Utility [00:05:23] Banking Control, Debanking & Stablecoins [00:07:40] Moore’s Law, Huang’s Law & The Limits of Silicon [00:08:45] Optical Computing Explained [00:09:12] NVIDIA, Parallelization & Power Consumption [00:10:24] Energy Constraints & The Electrical Grid [00:11:41] AI Energy Demand vs. Countries [00:12:24] Corporate AI Decision-Making at Scale [00:13:37] The Coming Explosion of AI Compute [00:14:20] Energy Efficiency vs. Speed [00:15:17] GPU Efficiency Improvements & Jevons Paradox [00:17:00] Why AI Is Different from Traditional Computing [00:17:47] Optical vs. Quantum vs. DNA Computing [00:18:19] Why Optical Computing Fits AI Perfectly [00:19:28] Precision, Bits & Neural Networks [00:21:24] Error Tolerance in AI Systems [00:22:00] Fiber Optics & Existing Infrastructure [00:23:16] New Computing Paradigms Beyond Silicon [00:24:00] Matrix Multiplication & AI Workloads [00:24:53] Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .

A Note from James: Is he the most hated man in America? I don’t think so. Martin Shkreli was notorious for various reasons that you’ll hear about in this episode—there are some crazy stories—but I’ve come to know Martin over the past few months as both a friend and business partner. Let’s just hear his stories and explanations. I think you’ll agree with me that this is one of the smartest people I’ve ever had on the podcast. Episode Description: Martin Shkreli became one of the most controversial figures in business history—labeled “the most hated man in America,” prosecuted, imprisoned, and publicly vilified. In this conversation, he tells his side of the story. Part 1 focuses on how media narratives form, why conviction and risk-taking matter in entrepreneurship, and the deeper mechanics behind the pharmaceutical controversy that made him famous. He explains the economics of drug pricing, insurance systems, neglected medications, and why public perception diverged so dramatically from what patients actually experienced. The episode also explores learning across disciplines, intellectual courage, prosecutors’ incentives, and how public scandals evolve into legal consequences. Whether you agree with him or not, the discussion raises uncomfortable questions about business, regulation, media, and reputation. What You’ll Learn: Why media narratives can shape public opinion more than facts The real economics behind pharmaceutical pricing and insurance coverage How entrepreneurs learn complex industries without formal training Why conviction and risk tolerance are essential in investing and business How incentives within legal and political systems influence outcomes Timestamped Chapters: [00:02:00] “Most Hated Man in America” — Media Narratives & Reputation [00:03:11] A Note from James [00:03:45] Humor vs. Backlash: Handling Public Criticism [00:06:39] Conviction, Investing & Standing Your Ground [00:09:00] Optimism, Forgiveness & Business Relationships [00:12:08] The Pharma Controversy Begins [00:14:52] From Hedge Funds to Biotech CEO [00:17:40] Learning New Industries from Scratch [00:19:00] Staying Curious & Avoiding Fear of Complexity [00:21:00] Borrowing Knowledge Across Domains [00:23:06] How People Actually Learn Complex Skills [00:29:00] Entrepreneurship, Ego & Motivation [00:31:20] The Daraprim Pricing Decision Explained [00:34:00] Neglected Drugs & Pharma Economics [00:37:00] Profit Motive vs. Public Good [00:41:13] Why He Became the Target [00:45:00] Prosecutors, Incentives & Legal Strategy [00:47:00] Hedge Funds, Technical Violations & Trials [00:50:00] High-Profile Cases & Selective Enforcement [00:53:00] Media Attention & Personal Decisions See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .

Martin Shkreli is the co-founder of DL Software, the parent company of Godel Terminal , a Bloomberg competitor for financial data. He previously founded the biotech companies Retrophin and Turing Pharmaceuticals and the hedge fund MSMB Capital Management. In this episode of Summation, Martin and Auren discuss: The structural reasons fintech is less competitive than other industries How drug discovery actually works (and doing it from prison) Why AI labs are now out-recruiting hedge funds What Martin learned from being "the most hated man in America" You can find Auren Hoffman on X at @auren and Martin Shkreli on X at @MartinShkreli

(01:19) - Timeline (20:53) - Range Rover Launches New Logo (29:07) - Martin Shkreli. Martin is an American entrepreneur and former pharmaceutical executive known for his work in biotechnology and hedge fund management. He co-founded the hedge funds Elea Capital, MSMB Capital Management, and the biopharmaceutical companies Retrophin and Turing Pharmaceuticals. Shkreli gained national attention during his tenure at Turing, and later faced legal issues related to securities fraud, for which he was convicted in 2017. Despite his controversial public image, he remains a notable figure in the biotech and finance communities. (01:21:40) - Timeline (01:36:11) - Joseph Krause, co-founder and CEO of Radical AI, announced the company's $55 million seed funding round, led by RTX Ventures, marking one of the largest in New York's history. He discussed plans to build an advanced materials R&D facility integrating AI and robotics to accelerate materials science innovation. Krause also shared his background in nanoscience and the journey from academic research to entrepreneurship, emphasizing the importance of culture and lean operations in their growth strategy. (01:45:29) - Timeline (01:53:20) - Joe Weisenthal is an American journalist and financial expert. He serves as the executive editor of news for Bloomberg Digital, co-anchors Bloomberg Television's "What’d You Miss?", and co-hosts the "Odd Lots" podcast. In the conversation, Weisenthal discusses recent positive economic data, including better-than-expected retail sales and jobless claims, and explores the implications of potential Federal Reserve rate cuts on long-term interest rates and mortgage rates. (02:23:53) - Nirav Tolia, co-founder and CEO of Nextdoor, recently discussed the platform's comprehensive redesign aimed at enhancing user engagement and utility. The new Nextdoor introduces three core features: 'News,' integrating content from over 3,500 local publications; 'Alerts,' providing real-time updates on local emergencies; and 'Faves,' an AI-powered tool offering personalized recommendations based on neighborhood conversations. Tolia emphasized that these enhancements are designed to make Nextdoor an indispensable daily resource for neighbors, fostering stronger, safer, and more connected communities. (02:40:13) - Mike Knoop, co-founder of Zapier and host of the ARC Prize, discusses the ARC-AGI benchmark's role in measuring AI's ability to generalize on novel tasks, emphasizing that while AI systems have made progress, they still lag behind human efficiency levels. He highlights the ARC Prize's aim to accelerate AGI development by encouraging open sharing of new ideas and fostering a diverse AI research community. Knoop also introduces ARC V3, an interactive reasoning benchmark designed to challenge emerging AI agent systems, noting its increased complexity and the importance of efficiency constraints to prevent agents from relying on brute-force methods. (03:00:58) - Kyle Samani, co-founder and managing partner at Multicoin Capital, discusses the transformative potential of stablecoins in enabling global access to U.S. dollars, emphasizing that this unprecedented shift is not yet fully appreciated. He highlights the profound implications for global commerce and payments, noting that major consumer software platforms can now legally integrate stablecoins, potentially onboarding billions of users into the crypto ecosystem. Samani also touches on the evolving regulatory landscape, mentioning the passage of the Genius Act and the anticipated Clarity Act, which aim to define regulatory responsibilities and provide clarity for the industry. TBPN.com is made possible by: Ramp - https://ramp.com Figma - https://figma.com Vanta - https://vanta.com Linear - https://linear.app Eight Sleep - https://eightsleep.com/tbpn Wander - https://

🍕 Pentagon Pizza Index: Reading Geopolitical Tea Leaves - Ever noticed takeout orders spike near the Pentagon before major crises? Sometimes unconventional data points can provide valuable market sentiment insights 🧬 Martin Shkreli's Quantum Computing Crusade - The controversial pharma entrepreneur turned quantum computing bear makes his case for why the sector is a massive bubble. We dissect his debate performance and whether his "never ever" stance goes too far ⚡ EOS Energy Options Strategy Deep Dive - Krzysztof breaks down his sophisticated options play on EOS after the stock's 40% crash, using standard deviation calculations and long-dated LEAPs to maximize leverage while managing risk 📃 Immigration Policy Reality Check - Luke explains why he sold Remitly after Trump's immigration promises didn't materialize as expected $RELY 🎰 The Psychology of Cutting Losses - Poker lessons applied to investing: why folding a position (even at a loss) often separates beginners from pros, and how price anchoring can destroy portfolios 🌴 Thank you for supporting Wall Street Wildlife on Patreon! 💵 Your support helps us continue bringing you valuable insights and market analysis Segments: 00:00 Introduction 00:45 Pentagon Pizza Index: Food Orders Predict Crises 08:45 Open Source Intelligence and Flight Tracking 12:12 Technical Analysis: Valid Tool or Voodoo? 15:57 Martin Shkreli: The Quantum Computing Bear 25:00 Gartner Hype Cycle and Quantum Bubble Dynamics 27:59 Shkreli's Character and Investment Credibility 32:37 Quantum Computing Short Strategies 33:01 EOS Energy Options Play Breakdown $EOSE 41:02 Options Strategy: Standard Deviation and LEAPs 45:25 Immigration Policy and Remitly Exit $RELY 48:57 Poker Psychology: Folding Winners and Cutting Losses ********** If you want to see our furry faces, this podcast is also available on YouTube at ⁠ https://www.youtube.com/@WallStreetWildlife?sub_confirmation=1⁠ ********** SUPPORT THE SHOW AND BECOME A PATREON: https://patreon.com/wallstreetwildlife ********** Find more episodes of the podcast at ⁠⁠⁠ wallstreetwildlife.com⁠⁠⁠ where you can also get our "10 Laws of the Investing Jungle" free PDF download, and you can follow us at: ⁠⁠ x.com/7LukeHallard ⁠ x.com/7FlyingPlatypus Wall Street Wildlife is also on Instagram @wallstreetwildlife ********** FinChat is the Complete Stock Research Platform for fundamental investors. With its beautiful design and institutional-quality data, FinChat is incredibly powerful and easy to use. Get 15% off any premium plan with: https://fiscal.ai/wildlife ********** Listen to the Chit Chat Stocks Podcast for discussions on stocks, financial markets, super investors, and more. Follow the show on Spotify, Apple Podcasts, or YouTube https://open.spotify.com/show/4SBtOWGEOmD9pmltgIXO8r ********** To use the same portfolio tracking tool as Luke, check-out: ⁠ https://www.portseido.com/?fpr=lukehallard ********** Monkey’s “Zen, Nietzsche, How to Live” Substack: <p

In this episode of Gradient Dissent, Lukas Biewald talks with Martin Shkreli — the infamous "pharma bro" turned founder — about his path from hedge fund manager and pharma CEO to convicted felon and now software entrepreneur. Shkreli shares his side of the drug pricing controversy, reflects on his prison experience, and explains how he rebuilt his life and business after being "canceled." They dive deep into AI and drug discovery, where Shkreli delivers a strong critique of mainstream approaches. He also talks about his latest venture in finance software, building Godel Terminal “a Vim for traders", and why he thinks the AI hype cycle is just beginning. It's a wide-ranging and candid conversation with one of the most controversial figures in tech and biotech. Follow Martin Shkreli on Twitter Godel Terminal: https://godelterminal.com/ Follow Weights & Biases on Twitter https://www.linkedin.com/company/wandb Join the Weights & Biases Discord Server: https://discord.gg/CkZKRNnaf3

Martin Shkreli jacked up drug prices, trolled the world, and bought a two million-dollar Wu-Tang album before the age of 35. But the karma (and real) police came for the Pharma Bro when the world caught wind of his price-gouging antics on life saving medicine. From hedge fund schemes to court-room memes, Martin earned the now infamous title of “Most Hated Man in America”. Kyle Prue (How to Piss Off Men) and Miles Bonsignore (Perfect Person, Try Guys) join Misha to give Martin Shkreli a taste of his own medicine. Follow The Big Flop on the Wondery app or wherever you get your podcasts. You can listen to The Big Flop early and ad-free on Wondery+. Join Wondery+ in the Wondery app or on Apple Podcasts. Be the first to know about Wondery’s newest podcasts, curated recommendations, and more! Sign up now at https://wondery.fm/wonderynewsletter Listen to The Big Flop on the Wondery App or wherever you get your podcasts. You can listen early and ad-free on Wondery+. Join Wondery+ in the Wondery App, Apple Podcasts or Spotify. Start your free trial by visiting wondery.com/links/the-big-flop/ now. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .

Martin Shkreli is America’s most hated pharma bro. In 2015 he bought daraprim which treats HIV and AIDS induced toxoplasmosis and raised the price dramatically. When questioned, he trolled reporters and the public, while actually accommodating a large majority of requests that needed the drug more cheaply. In doing this, he exposed behavior engaged in constantly by big pharma. In this episode, we talk heterodox health, biology and general science. TIMESTAMPS: Intro: 0:00 Shkreli on Being a Troll: 3:04 Turing & A.I.: 4:15 Anti-Aging: 11:00 Trippy Beliefs & Religion: 13:36 A.I.: 15:00 Human Evolution & Health: 20:56 Shkreli's Prison Time: 23:27 Love Life: 24:24 New Startup & Business: 27:04 A.I. & Crypto: 33:05 Who is Satoshi: 36:37 Favorite Books & Prison Time: 37:51 Information Theory: 42:41 Top 5 Rappers: 47:06 Hillary Clinton: 52:03 Martin's Trial: 55:21 Pharma & Medical System: 1:02:56 Was C0VlD Man-Made?: 1:11:56 Relationships & Marriage: 1:22:12 Autism Spectrum: 1:27:59 Being Misunderstood & OnlyFans: 1:32:11 *** AMERICAN ALCHEMY is an original series hosted by Jesse Michels that explores the frontier of science and tech. Each week, we bring you exclusive interviews with some of the leading thinkers of our time. INSTAGRAM ➤ https://www.instagram.com/jessemichels TWITTER ➤ https://twitter.com/AlchemyAmerican EMAIL/BOOKINGS ➤ usa.alchemy@gmail.com SUBSCRIBE TO OUR CHANNEL: https://www.youtube.com/channel/UC7eOJzNRWY4l2UTDvIquxYg?app=desktop original music: https://open.spotify.com/artist/6LlLRudDi60Uy4jcmOSEs1 - martin shkreli pharma bro Elea Capital wu tang clan investing daraprim Learn more about your ad choices. Visit megaphone.fm/adchoices

EPISODE #66: Martin Shkreli is back on the pod to discuss Kamala’s economic policies. We break down all of the details and why they are terrible ideas. The DNC is wrapped up, and we react to the events of the week. The media came after Ben Horowitz and his wife because.. wait for it.. they support Trump. And finally.. the most anticipated event of the week.. PIRATE IDOL. Shkreli is our guest judge this week as 4 contestants compete to earn a regular contributor spot on the Pirate Wires Podcast. Featuring Mike Solana, Brandon Gorrell, Riley Nork, Martin Shkreli Sign Up To Pirate Wires For Free! https://piratewires.co/free_newsletter Topics Discussed: https://www.piratewires.com/p/death-by-vibes Pirate Wires Twitter: https://twitter.com/PirateWires Mike Twitter: https://twitter.com/micsolana Brandon Twitter: https://twitter.com/brandongorrell Riley Twitter: https://x.com/rylzdigital Martin Twitter: https://x.com/MartinShkreli TIMESTAMPS: 0:00 - Welcome Back Martin Shkreli to the pod! 2:00 - Breadlines Are Brat - Breaking Down Kamala’s Economic Policy 16:45 - Price Gauging 26:30 - The Latest Polymarket Report 28:15 - DNC Recap - Including Land Acknowledgements, Vasectomies, and Free Abortions 46:15 - Media Attacks Ben Horowitz and His Wife For Supporting Trump 59:10 - PIRATE IDOL - Who’s Going To Be The Next PW Star?! 1:37:30 - Thanks For Watching! Like & Subscribe #podcast #technology #politics #culture

Martin Shkreli detailed his life story in a new VladTV exclusive. The infamous investor and businessman described growing up in Brooklyn with his parents, who were Albanian immigrants. He talked about his early passion for finance, which led him to join hedge fund Cramer Berkowitz shortly after college. During his young career, Shkreli found success in the pharmaceutical industry and was a millionaire by 28 years old. He also explained his controversial decision to raise prices on various medicines used for various illnesses. Later in the interview, he detailed his $1.5 million purchase of Wu-Tang Clan's one-of-a-kind "Once Upon a Time in Shaolin" album and his public feuds with Ghostface Killah, DJ Akademiks and Lil Wayne. Shkreli opened up about his securities fraud case and serving over four years in prison. To hear what Martin Shkreli has been up to since his release, check out the full interview above.